植物TBP及其相关因子（TAFs）的分子功能研究进展

摘要/Abstract

摘要： TATA结合蛋白(TATA binding protein, TBP)和TBP相关因子(TBP associated factors, TAFs)是构成通用转录因子TFIID复合物的核心亚基。TFIID作为RNA聚合酶II介导的转录起始关键调控元件，在启动子识别和建立前起始复合体中发挥着至关重要的作用。近来越来越多的研究发现，TBP和TAFs不仅参与核心启动子激活，还调控了植物器官分化、育性、开花时间、激素响应以及逆境适应性等关键生物学过程。本文系统综述了植物中TBP和TAFs的分子功能研究进展，包括TBP和TAFs蛋白的结构特征，在基础转录中的核心作用，以及调控植物生长发育、生物胁迫和非生物胁迫响应等，以期为作物性状改良提供新的转录调控基因靶点和思路。

关键词: TATA结合蛋白, TATA结合蛋白相关因子, 结构特征, 分子功能, 生长发育, 生物/非生物胁迫

Abstract: The TATA-binding protein (TBP) and TBP-associated factors (TAFs) constitute the core subunits of the general transcription factor TFIID complex. As a key regulatory element for RNA polymerase II-mediated transcription initiation, TFIID plays a crucial role in promoter recognition and the assembly of the preinitiation complex. Recent studies have increasingly revealed that TBP and TAFs are not only involved in core promoter activation but also regulate critical biological processes in plants, including organ differentiation, fertility, flowering time, hormone responses, and stress adaptation. This review systematically summarizes the research advances in understanding the molecular functions of TBP and TAFs in plants. It encompasses the structural features of TBP and TAF proteins and their core roles in basal transcription, as well as their regulation of plant growth and development, and responses to biotic and abiotic stresses. This synthesis aims to provide novel transcriptional regulatory gene targets and new strategies for crop trait improvement.

Key words: TBP, TAFs, structural features, molecular function, growth and development, biotic/abiotic stress

吴然然郑雪莹王宇张怡贾琪源袁星星杜吉到陈新. 植物TBP及其相关因子（TAFs）的分子功能研究进展. 植物学报.

Ran-ran Wu Xing XingYuan Ji-Dao DU Xin -Chen. Research progress on the molecular functions of plant TBP and its associated factors (TAFs). Chinese Bulletin of Botany.

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