植物TBP及其相关因子（TAFs）的分子功能研究进展

doi:10.11983/CBB25162

植物学报

植物TBP及其相关因子（TAFs）的分子功能研究进展

吴然然¹^†, 郑雪莹^1,
2^†, 王宇^1,
2, 张怡^{1, 2}, 贾琪源^{1, 3}, 袁星星¹ , 杜吉到², 陈新^1,
2*

¹江苏省农业科学院经济作物研究所, 江苏南京210014; ²黑龙江八一农垦大学农学院, 黑龙江大庆163319; ³南京农业大学生命科学学院, 江苏南京210095

收稿日期:2025-09-04 修回日期:2025-10-24 出版日期:2025-11-11 发布日期:2025-11-11
通讯作者: 陈新
基金资助:
国家重点研发计划(No.2024YFF1000504/2024YFF1000500)和国家食用豆产业技术体系首席科学家/岗位科学家项目(No.CARS-08)

Research Progress on the Molecular Functions of Plant TBP and its Associated Factors (TAFs)

Ranran Wu¹^†, Xueying Zheng^{1, 2}^†, Qiyuan Jia^{1, 3}, Yu Wang^{1, 2}, Yi Zhang^{1, 2}, Xingxing Yuan¹, Jidao Du², Xin Chen^{1, 2*}

¹Institute of Industrial Crops, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; ²College of Agriculture, Heilongjiang Bayi Agricultural University, Daqing 163319, China; ³College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China

Received:2025-09-04 Revised:2025-10-24 Online:2025-11-11 Published:2025-11-11
Contact: Xin Chen

摘要/Abstract

摘要： TATA结合蛋白(TATA binding protein, TBP)和TBP相关因子(TBP associated factors, TAFs)是构成通用转录因子TFIID复合物的核心亚基。TFIID作为RNA聚合酶II介导的转录起始关键调控元件, 在启动子识别和建立前起始复合体中发挥着至关重要的作用。近来越来越多的研究发现, TBP和TAFs不仅参与核心启动子激活, 还调控了植物器官分化、育性、开花时间、激素响应以及逆境适应性等关键生物学过程。本文系统综述了植物中TBP和TAFs的分子功能研究进展, 包括TBP和TAFs蛋白的结构特征, 在基础转录中的核心作用, 以及调控植物生长发育、生物胁迫和非生物胁迫响应等, 以期为作物性状改良提供新的转录调控基因靶点和思路。

关键词: TATA结合蛋白, TATA结合蛋白相关因子, 结构特征, 分子功能, 生长发育, 生物/非生物胁迫

Abstract: The TATA-binding protein (TBP) and TBP-associated factors (TAFs) constitute the core subunits of the general transcription factor TFIID complex. As a key regulatory element for RNA polymerase II-mediated transcription initiation, TFIID plays a crucial role in promoter recognition and the assembly of the preinitiation complex. Recent studies have increasingly revealed that TBP and TAFs are not only involved in core promoter activation but also regulate critical biological processes in plants, including organ differentiation, fertility, flowering time, hormone responses, and stress adaptation. This review systematically summarizes the research advances in understanding the molecular functions of TBP and TAFs in plants. It encompasses the structural features of TBP and TAF proteins and their core roles in basal transcription, as well as their regulation of plant growth and development, and responses to biotic and abiotic stresses. This synthesis aims to provide novel transcriptional regulatory gene targets and new strategies for crop trait improvement.

Key words: TBP, TAFs, structural features, molecular function, growth and development, biotic/abiotic stress

吴然然, 郑雪莹, 王宇, 张怡, 贾琪源, 袁星星, 杜吉到, 陈新. 植物TBP及其相关因子（TAFs）的分子功能研究进展. 植物学报, DOI: 10.11983/CBB25162.

Ranran Wu, Xueying Zheng, Qiyuan Jia, Yu Wang, Yi Zhang, Xingxing Yuan, Jidao Du, Xin Chen. Research Progress on the Molecular Functions of Plant TBP and its Associated Factors (TAFs). Chinese Bulletin of Botany, DOI: 10.11983/CBB25162.

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植物TBP及其相关因子（TAFs）的分子功能研究进展

Research Progress on the Molecular Functions of Plant TBP and its Associated Factors (TAFs)

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