植物Aux/IAA基因家族生物学功能研究进展

doi:10.11983/CBB21168

植物学报 ›› 2022, Vol. 57 ›› Issue (1): 30-41.DOI: 10.11983/CBB21168

植物Aux/IAA基因家族生物学功能研究进展

李艳艳¹, 齐艳华¹^,²^,^*()

¹内蒙古师范大学生命科学与技术学院, 呼和浩特 010022
²内蒙古大学生命科学学院, 牧草与特色作物生物学教育部重点实验室, 内蒙古自治区牧草与特色作物生物技术重点实验室, 呼和浩特 010000

收稿日期:2021-09-24 接受日期:2021-12-28 出版日期:2022-01-01 发布日期:2022-01-17
通讯作者: 齐艳华
作者简介:* E-mail: qyhjp@zju.edu.cn
基金资助:
国家自然科学基金地区项目(32060451);浙江省自然科学基金重点项目(LZ19C020001)

Advances in Biological Functions of Aux/IAA Gene Family in Plants

Yanyan Li¹, Yanhua Qi¹^,²^,^*()

¹College of Life Science and Technology, Inner Mongolia Normal University, Hohhot 010022, China
²Inner Mongolia Key Laboratory of Herbage & Endemic Crop Biotechnology, Key Laboratory of Herbage & Endemic Crop Biology of Ministry of Education, School of Life Sciences, Inner Mongolia University, Hohhot 010000, China

Received:2021-09-24 Accepted:2021-12-28 Online:2022-01-01 Published:2022-01-17
Contact: Yanhua Qi

摘要/Abstract

摘要： 生长素是最重要的植物激素之一, 对植物生长发育起着关键调控作用。生长素作用于植物后, 早期生长素响应基因家族Aux/IAA、GH3和SAUR等被迅速诱导, 基因表达上调。其中Aux/IAA基因家族编码的蛋白一般由4个保守结构域组成, 结构域I具有抑制生长素信号下游基因表达的作用, 结构域II在生长素信号转导中主要被TIR1调控进而影响Aux/IAA的稳定性, 结构域III/IV通过与生长素响应因子ARF相互作用调控生长素信号。Aux/IAA基因家族在双子叶植物拟南芥(Arabidopsis thaliana)的器官发育、根形成、茎伸长和叶扩张等方面发挥重要作用; 在单子叶植物水稻(Oryza sativa)和小麦(Triticum aestivum)中, 主要影响根系发育和株型, 但大多数Aux/IAA基因的功能尚不清楚。该文主要从Aux/IAA蛋白的结构、功能和生长素信号转导途径方面综述Aux/IAA家族在拟南芥、禾谷类作物及其它植物中的研究进展, 以期为全面揭示Aux/IAA家族基因的生物学功能提供线索。

关键词: Aux/IAA蛋白, 生长素, 拟南芥, 生物学功能, 禾谷类作物

Abstract: Auxin is one of the most important plant hormones and plays a key role in regulating plant growth and development. In plants, early auxin responsive gene families, such as Aux/IAA (Auxin/Indole acetic acid repressors), GH3 (Gretchen Hagen3) and SAUR (Small Auxin up RNA), are rapidly induced and up-regulated by auxin treatment. Aux/IAA gene family is generally composed of four conserved domains. Domain I inhibits the expression of downstream genes in the auxin signaling pathway, and domain II is mainly regulated by Transport Inhibitor Response 1 (TIR1) in auxin signal transduction, thus affecting the stability of Aux/IAA. Domain III/IV regulates auxin signaling by interacting with Auxin Response Factor (ARF). Aux/IAA gene family has been reported to play an important role in organ development, root formation, stem elongation and leaf expansion in dicotyledonous Arabidopsis thaliana while in monocotyledonous rice (Oryza sativa) and wheat (Triticum aestivum), Aux/IAA mainly affects root development and plant architecture. However, the functions of most Aux/IAA genes remain unclear and need to further study. In this article, we reviewed the structure and function of Aux/IAA protein, and the auxin signal transduction pathway in Arabidopsis, cereal crops and other plants to provide clues for fully revealing the biofunction of the Aux/IAA gene family.

Key words: Aux/IAA protein, auxin, Arabidopsis thaliana, biofunctions, cereal crops

李艳艳, 齐艳华. 植物Aux/IAA基因家族生物学功能研究进展. 植物学报, 2022, 57(1): 30-41.

Yanyan Li, Yanhua Qi. Advances in Biological Functions of Aux/IAA Gene Family in Plants. Chinese Bulletin of Botany, 2022, 57(1): 30-41.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB21168

https://www.chinbullbotany.com/CN/Y2022/V57/I1/30

图/表 6

图1 Aux/IAA蛋白的结构和功能域(Colón-Carmona et al., 2000; Szemenyei et al., 2008) TPL-IAA12/BDL-ARF5/MP: 转录共抑制因子TPL (TOPLESS)与受IAA12/BDL调控的生长素响应因子ARF5/MP相互作用; NLS: 核定位序列; Aux/IAAs-ARFs: Aux/IAA蛋白与ARF蛋白互作

Figure 1 Structure and functional domains of Aux/IAA protein (Colón-Carmona et al., 2000; Szemenyei et al., 2008) TPL-IAA12/BDL-ARF5/MP: Transcription co-inhibitor TOPLESS (TPL) interacts with ARF5/MONOPTEROS (ARF5/MP) regulated by IAA12/BODENLOS (IAA12/BDL); NLS: Nuclear localization sequence; Aux/IAAs-ARFs: Aux/IAA protein interacts with ARF protein

图2 经典的生长素信号转导途径(Woodward and Bartel, 2005; Leyser, 2018) (A) 高浓度生长素水平下TIR1介导的信号转导途径; (B) 低浓度生长素水平下TIR1介导的信号转导途径。TIR1/AFB: 转运抑制剂反应1/生长素信号F-box; Skp1、Culin和Rbx1: SCF型E3泛素蛋白连接酶复合物; Ub: 泛素; E1: 泛素活化酶; E2: 泛素结合酶; Aux/IAA: 早期生长素响应基因; ARF: 生长素响应因子; AREs: 生长素响应元件; TPL: TOPLESS

Figure 2 Canonical auxin signaling pathway (Woodward and Bartel, 2005; Leyser, 2018) (A) TIR1-mediated signaling pathway under high auxin concentration; (B) TIR1-mediated signaling pathway under low auxin concentration. TIR1/AFB: Transport inhibitor response 1/Auxin signaling F-box; Skp1, Culin and Rbx1: SCF-type ubiquitin protein ligase E3; Ub: Ubiquitin; E1: Ubiquitin activating enzyme; E2: Ubiquitin conjugating enzyme; Aux/IAA: Auxin/indole acetic acid repressors; ARF: Auxin response factor; AREs: Auxin response element; TPL: TOPLESS

图3 非经典生长素信号转导途径(Cao et al., 2019; Lv et al., 2020) (A) 生长素介导的TMK1-IAA32/34-ARFs信号转导途径; (B) 生长素介导的MPK14-IAA33-ARFs信号转导途径。TMK1C: 跨膜激酶1的羧基端; MPK14: 促有丝分裂活化蛋白激酶14

Figure 3 Non-canonical auxin signaling pathway (Cao et al., 2019; Lv et al., 2020) (A) Auxin mediates the TMK1-IAA32/34-ARFs signaling pathway; (B) Auxin mediates the MPK14-IAA33-ARFs signaling pathway. TMK1C: C-terminal of transmembrane kinase 1; MPK14: MITOGEN-ACTIVATED PROTEIN KINASE 14

表1 拟南芥Aux/IAA基因的生物学功能

Table 1 Biofunctions of Aux/IAA genes in Arabidopsis thaliana

基因名称	功能	参考文献
AtIAA3	调控侧根数目与长度, 及下胚轴长度和子叶大小	Tian and Reed, 1999
AtIAA5/AtIAA6/AtIAA19	调控拟南芥的耐旱性	Salehin et al., 2019
AtIAA7	参与植物的向地性生长	Wilson et al., 1990; Timpte et al., 1994
AtIAA8	调节花器官发育	王婧, 2012
AtIAA14	调控植物侧根和根毛的数量	López-Bucio et al., 2015
AtIAA17	调控植物下胚轴长度、根毛数量及叶形态	Rouse et al., 1998
AtIAA18	调控侧根的形成	Uehara et al., 2008; López-Bucio et al., 2015
AtIAA19	调控下胚轴和侧根的形成	Harper et al., 2000
AtIAA28	参与侧根的形成	Rogg et al., 2001
AtIAA32/34	调控顶端弯钩发育	Cao et al., 2019
AtIAA33	维持根尖干细胞活性	Lv et al., 2020

表2 水稻Aux/IAA基因的生物学功能

Table 2 Biofunctions of Aux/IAA genes in rice

基因名称	功能	参考文献
OsIAA1	调控株高和叶夹角	Song et al., 2009
OsIAA3/OsIAA17	参与调控籽粒长度和叶夹角	张战营, 2015
OslAA4	调控株高、叶夹角、分蘖角和向重力性	Song and Xu, 2013
OsIAA6	调控分蘖数和参与干旱胁迫响应	Jung et al., 2015
OsIAA11	参与侧根的形成	Zhu et al., 2012
OsIAA12	调控叶夹角	Chen et al., 2018
OsIAA13	调控侧根数目	Kitomi et al., 2012
OsIAA16	调控独脚金内酯水平从而影响水稻分蘖	王闵霞, 2016
OsIAA20	参与干旱和盐胁迫响应	Zhang et al., 2021
OslAA23	调控根冠生长状态, 使根终止生长	Ni et al., 2011
OsIAA31	调控叶和根冠生长	Nakamura et al., 2006

表3 其它植物Aux/IAA基因的生物学功能

Table 3 Biofunctions of Aux/IAA genes in other plants

物种	基因名称	功能	参考文献
小麦(Triticum aestivum)	TaIAA1	参与调控光敏性	Singla et al., 2006
	TaIAA7	参与调控根系生长	Chen et al., 2016
	TaIAA8	调控侧根数目	刘艳娜, 2020
	TaIAA21	调控小麦籽粒大小和粒重	Jia et al., 2021
番茄(Lycopersicon esculentum)	SlIAA3	主要参与番茄的生长发育	Chaaboun et al., 2009
	SlIAA9	参与果实发育和叶形态建成	Zhang et al., 2007
	SlIAA15	参与叶和侧根的发育	Deng et al., 2012
	SlIAA17	调控番茄肉质果实的大小	Su et al., 2014, 2015
	SlIAA27	参与番茄根、叶、花和器官的生长发育	Bassa et al., 2012
陆地棉(Gossypium hirsutum)	GhIAA4/GhIAA5	参与棉纤维的起始	Han et al., 2012; 王曦烨, 2016
	GhIAA8	参与早期纤维的伸长, 与次生壁合成有关	Han et al., 2012
马铃薯(Solanum tuberosum)	StIAA2	调控株高、叶柄和茎的生长发育	Kloosterman et al., 2006
	StIAA9	参与马铃薯块茎的形成和发育	Gao et al., 2016

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植物Aux/IAA基因家族生物学功能研究进展

Advances in Biological Functions of Aux/IAA Gene Family in Plants

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