植物ABCB亚家族生物学功能研究进展

doi:10.11983/CBB19140

摘要/Abstract

摘要： ABC转运蛋白超家族结构和功能复杂多样, 包含ABCA-ABCH八个亚家族。ABCB是ABC转运蛋白的一个亚家族, 多数定位于质膜, 少数定位于线粒体膜或叶绿体膜。ABCB与其它生长素转运蛋白(AUX1/LAX、PIN)共同参与调控植物生长素的极性运输, 在植物生长发育的各个阶段发挥作用。此外, ABCB转运蛋白还调控植物的向性运动和重金属抗性等过程。近年来, 随着越来越多植物全基因组测序的完成, ABCB亚家族在禾谷类单子叶植物水稻(Oryza sativa)、玉米(Zea mays)和高粱(Sorghum bicolor)中的生物学功能开始有少量报道, 然而多数ABCB转运蛋白的功能尚未得到阐释。该文对拟南芥(Arabidopsis thaliana)和禾谷类作物ABCB转运蛋白的研究进展进行综述, 以期为全面揭示ABCB亚家族生物学功能提供线索。

关键词: ABCB转运蛋白, 禾谷类作物, 拟南芥, 生长素, 生物学功能

Abstract: The superfamily of ABC (ATP-binding cassette) transporters, which contains eight subfamilies from ABCA to ABCH, has diverse structures and complex functions. ABCB transporters, are mostly located in the plasma membrane, while others are located in the mitochondrial membrane or chloroplast membrane. ABCB transporters, together with AUX1/LAX (AUXIN1/LIKE AUXIN) and PIN (PIN-FORMED), coordinate and participate in the polar transport of auxin, and play an important role in regulating plant growth and development. ABCB transporters also function in plant tropism and resistance to heavy metals. In recent years, with the completion of whole-genome sequencing in different plants, research on ABCB genes is no longer confined to the model plant Arabidopsis thaliana, rather, preliminary studies have been carried out to explore the functions of ABCB genes in cereal including rice, maize, and sorghum. However, the functions for most of the plant ABCB transporters remain elusive. Here we reviewed the research progress and future development of ABCB subfamily transporters in Arabidopsis and cereal, in the hope of providing clues for fully revealing biofunctions of the ABCB subfamily.

Key words: ABCB transporter, cereal crops, Arabidopsis thaliana, auxin, biofunctions

贺祯媚,李东明,齐艳华. 植物ABCB亚家族生物学功能研究进展. 植物学报, 2019, 54(6): 688-698.

Zhenmei He,Dongming Li,Yanhua Qi. Advances in Biofunctions of the ABCB Subfamily in Plants. Chinese Bulletin of Botany, 2019, 54(6): 688-698.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB19140

https://www.chinbullbotany.com/CN/Y2019/V54/I6/688

图/表 5

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	类型	拟南芥	水稻
全分子转运蛋白	MDR (multidrug resistance)	22个 (AtABCB1- AtABCB22)	22个 (OsABCB1- OsABCB22)
半分子转运蛋白	ATM (ABC transporter of the mitochondria)	3个 (AtABCB23, AtABCB24和AtABCB25)	1个 (OsABCB23)
	TAP (transporter associated with antigen processing)	3个 (AtABCB26-AtABCB28)	3个 (OsABCB24- OsABCB26)
	LLP (prokaryotic lipid A- like exporters, putative)	1个 (AtABCB29)	1个 (OsABCB27)

	类型	拟南芥	水稻
全分子转运蛋白	MDR (multidrug resistance)	22个 (AtABCB1- AtABCB22)	22个 (OsABCB1- OsABCB22)
半分子转运蛋白	ATM (ABC transporter of the mitochondria)	3个 (AtABCB23, AtABCB24和AtABCB25)	1个 (OsABCB23)
	TAP (transporter associated with antigen processing)	3个 (AtABCB26-AtABCB28)	3个 (OsABCB24- OsABCB26)
	LLP (prokaryotic lipid A- like exporters, putative)	1个 (AtABCB29)	1个 (OsABCB27)

类型	基因名称	功能	参考文献
MDR (multidrug resistance)	AtABCB1/PGP1	参与地上部(花序轴、下胚轴)生长素输出, 促进下胚轴伸长	Sidler et al.,1998; Geisler et al., 2005
	AtABCB4/PGP4	在拟南芥根中表现为生长素兼性转运载体, 介导侧根及根毛发育	Santelia et al., 2005; Terasaka et al., 2005; Cho et al., 2007; Lewis et al., 2007; Kubeš et al., 2012
	AtABCB6	与AtABCB20在功能上冗余, 参与花序轴中生长素的向基转运	Zhang et al., 2018
	AtABCB14/MDR12	参与花序轴中生长素运输, 与花序轴维管发育和气孔开闭有关	Lee et al., 2008; Kaneda et al., 2011
	AtABCB15	参与花序轴中生长素运输	Kaneda et al., 2011
	AtABCB19/PGP19	参与地上部生长素向基运输以及根的向顶运输, 调控不定根发育及胚后器官分离	Noh et al., 2001; Lewis et al., 2007; Sukumar et al., 2013; Zhao et al., 2013
	AtABCB20	与AtABCB6在功能上冗余, 参与花序轴中生长素向基转运	Zhang et al., 2018
	AtABCB21	地上部生长素兼性运输载体, 参与生长素向顶转运, 调控生长素水平	Kamimoto et al., 2012; Jenness et al., 2019
ATM (ABC transporter of mitochondria)	AtABCB23/ATM1	参与铁硫簇输出	Chen et al., 2007
ATM (ABC transporter of mitochondria)	AtABCB24/ATM2	未知	Chen et al., 2007
	AtABCB25/ATM3	参与铁硫簇输出, 重金属抗性, 并参与调控钼辅因子合成	Kim et al., 2006; Chen et al., 2007; Bernard et al., 2009; Teschner et al., 2010
TAP (transporter associated with antigen processing)	AtABCB26/TAP1 AtABCB27/TAP2/ALS1	未知调控铝毒环境中根的发育	Ferro et al., 2010 Larsen et al., 2007; Zhu et al., 2013

类型	基因名称	功能	参考文献
MDR (multidrug resistance)	AtABCB1/PGP1	参与地上部(花序轴、下胚轴)生长素输出, 促进下胚轴伸长	Sidler et al.,1998; Geisler et al., 2005
	AtABCB4/PGP4	在拟南芥根中表现为生长素兼性转运载体, 介导侧根及根毛发育	Santelia et al., 2005; Terasaka et al., 2005; Cho et al., 2007; Lewis et al., 2007; Kubeš et al., 2012
	AtABCB6	与AtABCB20在功能上冗余, 参与花序轴中生长素的向基转运	Zhang et al., 2018
	AtABCB14/MDR12	参与花序轴中生长素运输, 与花序轴维管发育和气孔开闭有关	Lee et al., 2008; Kaneda et al., 2011
	AtABCB15	参与花序轴中生长素运输	Kaneda et al., 2011
	AtABCB19/PGP19	参与地上部生长素向基运输以及根的向顶运输, 调控不定根发育及胚后器官分离	Noh et al., 2001; Lewis et al., 2007; Sukumar et al., 2013; Zhao et al., 2013
	AtABCB20	与AtABCB6在功能上冗余, 参与花序轴中生长素向基转运	Zhang et al., 2018
	AtABCB21	地上部生长素兼性运输载体, 参与生长素向顶转运, 调控生长素水平	Kamimoto et al., 2012; Jenness et al., 2019
ATM (ABC transporter of mitochondria)	AtABCB23/ATM1	参与铁硫簇输出	Chen et al., 2007
ATM (ABC transporter of mitochondria)	AtABCB24/ATM2	未知	Chen et al., 2007
	AtABCB25/ATM3	参与铁硫簇输出, 重金属抗性, 并参与调控钼辅因子合成	Kim et al., 2006; Chen et al., 2007; Bernard et al., 2009; Teschner et al., 2010
TAP (transporter associated with antigen processing)	AtABCB26/TAP1 AtABCB27/TAP2/ALS1	未知调控铝毒环境中根的发育	Ferro et al., 2010 Larsen et al., 2007; Zhu et al., 2013

物种	基因名称	功能	参考文献
玉米	ZmABCB1	参与地上部生长素运输	Multani et al., 2003
高粱	SbABCB1	参与地上部生长素运输	Multani et al., 2003
小麦	TaMDR1	抗铝毒害	Sasaki et al., 2002
水稻	OsABCB14	参与根中生长素向顶运输, 铁离子平衡	Xu et al., 2014
	OsABCB23	铁硫聚簇装配	Zuo et al., 2017
	OsABCB27	铝胁迫响应	Huang et al., 2009