Chinese Bulletin of Botany ›› 2022, Vol. 57 ›› Issue (1): 80-89.DOI: 10.11983/CBB21120
• SPECIAL TOPICS • Previous Articles Next Articles
Jingwen Wang1, Xingjun Wang1,2, Changle Ma1, Pengcheng Li1,2,*()
Received:
2021-07-23
Accepted:
2021-10-12
Online:
2022-01-01
Published:
2022-01-17
Contact:
Pengcheng Li
Jingwen Wang, Xingjun Wang, Changle Ma, Pengcheng Li. A Review on the Mechanism of Ribosome Stress Response in Plants[J]. Chinese Bulletin of Botany, 2022, 57(1): 80-89.
Figure 1 Comparison of ribosomal stress and DNA damage response pathways between mammalian and plant cells Ribosomal stress can be resulted from mutations in genes encoding ribosomal proteins or defects in ribosome biogenesis. In mammalian cells, both ribosomal stress and DNA damage responses are mediated by p53. Under normal conditions, p53 interacts with E3 ubiquitin ligase MDM2, which regulates its protein homeostasis through ubiquitin degradation pathway; when ribosomal stress occurs, some RPs are released from the nucleolus and bind to the acidic domain of MDM2, leading to reduction of its effect on p53. p53 acts as a transcription factor to mediate downstream cell cycle arrest, cell aging and apoptosis. In plants, SOG1, a p53-like transcription factor that can be activated and phosphorylated by ATM and ATR, is involved in DNA damage response, but no evidence shows its involvement in ribosomal stress response. However, another NAC transcription factor, ANAC082, is reported to be involved in ribosomal stress response. Solid arrow indicates the normal state, the dotted arrows indicate stress state.
Figure 2 Ribosome biogenesis and the related function of MDN1 RNA Pol I: RNA polymerase I; RPSs/RPLs: Ribosomal proteins of the small/large subunit; ARFs: Auxin response factors; RBFs: Ribosomes biogenetic factors. In the process of ribosome biogenesis, both MDN1 and PES2 participate in the assembly of 60S subunits as RBFs. The MIDAS domain of MDN1 can interact with the UBL domain of PES2. When the 60S ribosome precursor is about to enter the nucleoplasm, MDN1 uses ‘mechanical force' to dissociate PES2 from the 60S precursor; at the nuclear export checkpoint, MDN1 is also dissociated from the 60S ribosomal particle. There is a coordination mechanism between auxin and ribosome biogenesis. Under normal conditions, auxin activates the expression of MDN1 through ARFs. When MDN1 is dysfunction (indicated by the red MDN1*), the accumulation of PIN2 protein increases while that of AUX1 and PIN1 decreases, probably leading to changes in both homeostasis and distribution of auxin in plants. Therefore, the auxin system may participate in the ribosomal stress response to regulate plant growth and development.
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