Advances in Iron Deficiency-induced Coumarin Biosynthesis and Their Functions in Iron Absorption in Plants

doi:10.11983/CBB24106

Abstract

Abstract: Coumarins are a class of phenolic compounds with benzopyrones as the parent ring structure, categorized into simple and complex coumarins, and widely distributed in higher plants. In recent years, studies have shown that root-secreted coumarins can promote iron absorption in plants. Here, the recent progress in the discovery and identification of genes related to the biosynthesis and regulation of plant iron deficiency-induced coumarins is reviewed, and the molecular mechanisms of the biosynthesis, storage, secretion, and regulation of iron deficiency-induced coumarins are further elaborated. The mechanism by which coumarins could promote plant iron uptake has also been discussed. Finally, this paper provides a preliminary outlook on the future research directions to gain knowledge of these mechanisms, which could offer novel opportunities to generate iron deficiency-tolerant crops and iron-biofortified crops.

Key words: iron deficiency, coumarin, biosynthesis, regulation, iron uptake

Zhou Jing, Gao Fei. Advances in Iron Deficiency-induced Coumarin Biosynthesis and Their Functions in Iron Absorption in Plants[J]. Chinese Bulletin of Botany, 2025, 60(3): 460-471.

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URL: https://www.chinbullbotany.com/EN/10.11983/CBB24106

https://www.chinbullbotany.com/EN/Y2025/V60/I3/460

Figures/Tables 3

References 68

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功能分类	基因	功能	缺铁应答	参考文献
香豆素前体合成	PAL	反式肉桂酸合成	诱导型	Rodríguez-Celma et al., 2013
	C4H	4-香豆酸合成	诱导型	Rodríguez-Celma et al., 2013
	4CL1/2	香豆酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
	HCT	咖啡酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
	CCoAOMT1	阿魏酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
香豆素合成	F6H'1	6'-羟基阿魏酰辅酶A合成	诱导型	Kai et al., 2008; Schmid et al., 2014
	COSY	莨菪亭合成	诱导型	Vanholme et al., 2019
	S8H	秦皮素合成	诱导型	Siwinska et al., 2018; Tsai et al., 2018
	CYP82C4	Sideretin合成	诱导型	Murgia et al., 2011
香豆素分泌	PDR9	香豆素类化合物外排分泌	诱导型	Rodríguez-Celma et al., 2013; Fourcroy et al., 2014
	BGLU42	莨菪苷去糖基化	诱导型	Ziegler et al., 2017
调控	FIT	正调控香豆素合成	诱导型	Schmid et al., 2014; Ziegler et al., 2016
	MYB72	正调控香豆素合成	诱导型	Stringlis et al., 2018
	MYB63	正调控香豆素合成	?	DeLoose et al., 2024
	bHLH121	正调控香豆素合成	组成型	Gao et al., 2020a
	MYB15	正调控香豆素合成	?	Schwarz and Bauer, 2020
	KFB1	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017
	KFB20	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017
	KFB50	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017

功能分类	基因	功能	缺铁应答	参考文献
香豆素前体合成	PAL	反式肉桂酸合成	诱导型	Rodríguez-Celma et al., 2013
	C4H	4-香豆酸合成	诱导型	Rodríguez-Celma et al., 2013
	4CL1/2	香豆酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
	HCT	咖啡酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
	CCoAOMT1	阿魏酰辅酶A合成	诱导型	Rodríguez-Celma et al., 2013
香豆素合成	F6H'1	6'-羟基阿魏酰辅酶A合成	诱导型	Kai et al., 2008; Schmid et al., 2014
	COSY	莨菪亭合成	诱导型	Vanholme et al., 2019
	S8H	秦皮素合成	诱导型	Siwinska et al., 2018; Tsai et al., 2018
	CYP82C4	Sideretin合成	诱导型	Murgia et al., 2011
香豆素分泌	PDR9	香豆素类化合物外排分泌	诱导型	Rodríguez-Celma et al., 2013; Fourcroy et al., 2014
	BGLU42	莨菪苷去糖基化	诱导型	Ziegler et al., 2017
调控	FIT	正调控香豆素合成	诱导型	Schmid et al., 2014; Ziegler et al., 2016
	MYB72	正调控香豆素合成	诱导型	Stringlis et al., 2018
	MYB63	正调控香豆素合成	?	DeLoose et al., 2024
	bHLH121	正调控香豆素合成	组成型	Gao et al., 2020a
	MYB15	正调控香豆素合成	?	Schwarz and Bauer, 2020
	KFB1	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017
	KFB20	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017
	KFB50	正调控香豆素合成	诱导型	Zhang et al., 2015; Chezem et al., 2017