Research Progress in Sirtuin Protein Family in Plants

doi:10.11983/CBB22255

Abstract

Abstract: The sirtuin protein family of plants is a class of enzymes that depend on β-nicotinamide adenine dinucleotide (β-NAD⁺) to catalyze the removal of N^ε-acetyl and N^ε-acyl (acetyl, crotonyl, butylyl and 2-hydroxy-isobutylyl) from non-histone and histone lysine, respectively, and has the function of regulating the activity of non-histone protein and gene expression. Members of the sirtuin protein family have been shown to play important epigentic regulatory roles in the growth and development of rice (Oryza sativa), soybean (Glycine max) and tomato (Solanum lycopersicum), and in response to salt, cold, heat and pathogen stresses. Here we summarized the recent research advances in the enzyme activity, catalytic substrates, cell localization and function of plant sirtuins, which will serve as a reference for understanding the epigenetic regulation mechanism and studying the new function of sirtuin.

Key words: plant, sirtuins, deacylation, epigenetic regulation, development, stress

Lufang Su, Ping Wang, Shun Li, Yan Cai, Dandan Guo, Qin Liu, Xiaoyun Liu. Research Progress in Sirtuin Protein Family in Plants[J]. Chinese Bulletin of Botany, 2023, 58(6): 998-1007.

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URL: https://www.chinbullbotany.com/EN/10.11983/CBB22255

https://www.chinbullbotany.com/EN/Y2023/V58/I6/998

Figures/Tables 3

References 55

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物种	蛋白名称	细胞定位	催化底物	酶活性	功能	参考文献
拟南芥 (Arabidopsis thaliana)	AtSRT1	细胞核	H3K9ac和AtMBP1	去乙酰基	非生物胁迫响应和叶片发育	Lee et al., 2016; Liu et al., 2017
	AtSRT2A	线粒体	ATP合酶和AAC1/2/3	去乙酰基	能量代谢	K?nig et al., 2014
	AtSRT2B	细胞核	H4K8	去乙酰基	盐胁迫响应	Tang et al., 2022
		细胞核	组蛋白和H3K9ac	去乙酰基	生长发育和病原菌胁迫响应	Wang et al., 2010
		线粒体	ATP合酶和AAC1/2/3	去乙酰基	能量代谢	K?nig et al., 2014
水稻 (Oryza sativa)	OsSRT1	细胞核	H3K9ac、OsGAPDH1/ 2/5和Khib	去乙酰基和去2-羟基异丁酰基	叶片衰老、种子发育、能量代谢和病原菌胁迫响应	Zhong et al., 2013; Fang et al., 2016; Zhang et al., 2016, 2017
	OsSRT2	细胞质	OsGAPDH1	去乙酰基	能量代谢	Lu et al., 2018
		线粒体	H3K9ac	去乙酰基	能量代谢	Chung et al., 2009; Lu et al., 2018
		细胞核	组蛋白和H3K9	去乙酰基、去巴豆酰基、去丁酰基和去2-羟基异丁酰基	黑暗、饥饿、淹水和病原菌胁迫响应	Lu et al., 2018; Chen et al., 2021
大豆 (Glycine max)	GmSRT1	细胞质和线粒体	H3组蛋白	去乙酰基	-	Yang et al., 2018
	GmSRT2	细胞质和线粒体	-	-	冷、热和盐胁迫响应	Yang et al., 2018
	GmSRT3	细胞质和细胞核	-	-	-	Yang et al., 2018
	GmSRT4	细胞核	-	-	冷、热和盐胁迫响应	Yang et al., 2018
番茄(Solanum lycopersicum)	SlSRT1	细胞核	-	-	子叶、花和果实发育	Zhao et al., 2015
番茄(Solanum lycopersicum)	SlSRT2	细胞核和细胞质	-	-	子叶、叶、花和果实发育	Zhao et al., 2015
葡萄(Vitis vinifera)	VvSRT1	细胞核和细胞质	-	-	根、叶、花和果实发育	Cucurachi et al., 2012
葡萄(Vitis vinifera)	VvSRT2	细胞质和线粒体	-	-	叶、花和果实发育	Cucurachi et al., 2012
地线 (Marchantia polymorpha)	MpSIRT4	线粒体	-	-	IAA和热胁迫响应	Chu and Chen, 2018
	MpSIRT5	线粒体	-	-	ABA响应	Chu and Chen, 2018
	MpSIRT6	细胞核和细胞质	-	-	-	Chu and Chen, 2018
三角褐指藻 (Phaeodacty- lum tricornutum)	PtSRT5	质体和细胞核	PtACSL1	去乙酰基	脂肪酸合成	Chen et al., 2018
	PtSRT3	-	-	-	-	Chen et al., 2018
	PtSRT2	-	-	-	-	Chen et al., 2018
	PtSRT4	-	-	-	-	Chen et al., 2018

物种	蛋白名称	细胞定位	催化底物	酶活性	功能	参考文献
拟南芥 (Arabidopsis thaliana)	AtSRT1	细胞核	H3K9ac和AtMBP1	去乙酰基	非生物胁迫响应和叶片发育	Lee et al., 2016; Liu et al., 2017
	AtSRT2A	线粒体	ATP合酶和AAC1/2/3	去乙酰基	能量代谢	K?nig et al., 2014
	AtSRT2B	细胞核	H4K8	去乙酰基	盐胁迫响应	Tang et al., 2022
		细胞核	组蛋白和H3K9ac	去乙酰基	生长发育和病原菌胁迫响应	Wang et al., 2010
		线粒体	ATP合酶和AAC1/2/3	去乙酰基	能量代谢	K?nig et al., 2014
水稻 (Oryza sativa)	OsSRT1	细胞核	H3K9ac、OsGAPDH1/ 2/5和Khib	去乙酰基和去2-羟基异丁酰基	叶片衰老、种子发育、能量代谢和病原菌胁迫响应	Zhong et al., 2013; Fang et al., 2016; Zhang et al., 2016, 2017
	OsSRT2	细胞质	OsGAPDH1	去乙酰基	能量代谢	Lu et al., 2018
		线粒体	H3K9ac	去乙酰基	能量代谢	Chung et al., 2009; Lu et al., 2018
		细胞核	组蛋白和H3K9	去乙酰基、去巴豆酰基、去丁酰基和去2-羟基异丁酰基	黑暗、饥饿、淹水和病原菌胁迫响应	Lu et al., 2018; Chen et al., 2021
大豆 (Glycine max)	GmSRT1	细胞质和线粒体	H3组蛋白	去乙酰基	-	Yang et al., 2018
	GmSRT2	细胞质和线粒体	-	-	冷、热和盐胁迫响应	Yang et al., 2018
	GmSRT3	细胞质和细胞核	-	-	-	Yang et al., 2018
	GmSRT4	细胞核	-	-	冷、热和盐胁迫响应	Yang et al., 2018
番茄(Solanum lycopersicum)	SlSRT1	细胞核	-	-	子叶、花和果实发育	Zhao et al., 2015
番茄(Solanum lycopersicum)	SlSRT2	细胞核和细胞质	-	-	子叶、叶、花和果实发育	Zhao et al., 2015
葡萄(Vitis vinifera)	VvSRT1	细胞核和细胞质	-	-	根、叶、花和果实发育	Cucurachi et al., 2012
葡萄(Vitis vinifera)	VvSRT2	细胞质和线粒体	-	-	叶、花和果实发育	Cucurachi et al., 2012
地线 (Marchantia polymorpha)	MpSIRT4	线粒体	-	-	IAA和热胁迫响应	Chu and Chen, 2018
	MpSIRT5	线粒体	-	-	ABA响应	Chu and Chen, 2018
	MpSIRT6	细胞核和细胞质	-	-	-	Chu and Chen, 2018
三角褐指藻 (Phaeodacty- lum tricornutum)	PtSRT5	质体和细胞核	PtACSL1	去乙酰基	脂肪酸合成	Chen et al., 2018
	PtSRT3	-	-	-	-	Chen et al., 2018
	PtSRT2	-	-	-	-	Chen et al., 2018
	PtSRT4	-	-	-	-	Chen et al., 2018