活性氧调控植物细胞自噬的研究进展

doi:10.11983/CBB18012

摘要/Abstract

摘要： 真核生物通过双层膜结构包裹细胞内受损的蛋白、细胞器或外源物质, 经溶酶体(或液泡)将内含物降解并进行循环利用, 这种高度保守的生物学过程称为自噬。活性氧是细胞有氧代谢的副产物, 作为一种信号分子广泛参与不同生物学过程的调控。研究表明, 真核生物中自噬与活性氧之间存在密切联系。该文结合近年的研究进展, 对植物细胞中活性氧的种类及作用和自噬的分子机制等进行概述, 旨在探讨活性氧对自噬的调控作用。

关键词: 自噬, 活性氧, 调控

Abstract: Damaged proteins, organelles or exogenous substances are engulfed in double membrane vesicles and delivered to the lysosome (vacuoles) for degradation and recycled in eukaryotes. This highly conserved biological process is called autophagy. Reactive oxygen species (ROS) are byproducts of cellular aerobic metabolism, which are widely involved in the regulating different biological processes as signaling molecules. Recent evidence suggests a strong link between autophagy and ROS in plants. Here, we summarize the types and roles of ROS and describe the molecular mechanism of autophagy according to the latest research in plants. The effect of ROS on regulation of autophagy is mainly discussed.

Key words: autophagy, reactive oxygen species, regulation

马丹颖,季东超,徐勇,陈彤,田世平. 活性氧调控植物细胞自噬的研究进展. 植物学报, 2019, 54(1): 81-92.

Danying Ma,Dongchao Ji,Yong Xu,Tong Chen,Shiping Tian. Advances in the Regulation on Autophagy by Reactive Oxygen Species in Plant Cells. Chinese Bulletin of Botany, 2019, 54(1): 81-92.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB18012

https://www.chinbullbotany.com/CN/Y2019/V54/I1/81

图/表 1

图1 植物细胞中不同来源的活性氧调控自噬(改自Pérez-Pérez et al., 2012b) 定位于质膜的NADPH氧化酶, 以及叶绿体、线粒体、过氧化物酶体和内质网等细胞器均能产生活性氧。过量的活性氧会诱导细胞自噬, 以减少活性氧的产生并清除细胞受损组分。NADPH: 烟酰胺腺嘌呤二核苷酸磷酸; O2: 氧分子; O2·-: 超氧阴离子; H2O2: 过氧化氢; 1O2: 单线态氧

Figure 1 Different reactive oxygen species (ROS) sources control autophagy in plant cells (modified from Pérez-Pérez et al., 2012b) ROS can be generated by plasma membrane-localized NOX and different organelles, including chloroplast, mitochondria, peroxisome, and endoplasmic reticulum. Excess ROS then induce autophagy, which contributes to down-regulate ROS production and remove damaged cellular components. NADPH: Reduced nicotinamide adenine dinucleotide phosphate; O2: Dioxygen; O2·-: Superoxide anion; H2O2: Hydrogen peroxide; 1O2: Singlet oxygen

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