Chinese Bulletin of Botany ›› 2019, Vol. 54 ›› Issue (3): 296-299.DOI: 10.11983/CBB19033

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Chinese Scientists Reveal Genome-wide Off-targeted Editing of Cytosine Base Editor

Kabin Xie()   

  1. National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
  • Received:2019-01-21 Accepted:2019-01-22 Online:2019-07-01 Published:2019-05-20
  • Contact: Kabin Xie

Abstract: Targeted base editing with CRISPR-Cas systems is a breakthrough in genome editing technologies and is widely used in studies of humans, animals and plants. Recently, Chinese scientists discovered that the cytosine base editor (CBE) including BE3 and HF1-BE3 but not the adenine base editor (ABE) has substantial promise for genome-wide off-targeted editing in rice. This discovery is of great significance to the application and further optimization of targeted base editing.

Key words: base editing, CRISPR, off-targeting