蛋白质翻译后修饰在ABA信号转导中的作用

doi:10.11983/CBB18217

摘要/Abstract

摘要： 脱落酸(ABA)是植物生长发育和逆境适应过程中非常关键的植物激素。植物响应ABA信号转导过程由信号识别、转导及响应级联完成, 其中心转导途径由ABA受体RCAR/PYR/PYLs、磷酸酶PP2Cs、激酶SnRK2s、转录因子和离子通道蛋白构成。蛋白磷酸化、泛素化、类泛素化和氧化还原等翻译后修饰在ABA转导途径中起重要作用。该文综述了翻译后修饰在ABA信号转导中的作用。

关键词: 脱落酸, 磷酸化, 翻译后修饰, 氧化还原修饰, 类泛素化, 泛素化

Abstract: Abscisic acid (ABA) plays a key role in the growth, development and stress condition of plants. The process of plant response to ABA is completed by signal recognition, transduction, and response cascades. The core ABA signaling pathway consists of receptor RCAR/PYR/PYLs, phosphatase PP2Cs, kinase SnRK2s, and transcription factors and ion channel proteins. Post-translational modifications (PTMs) of proteins such as phosphorylation, ubiquitination, small ubi- quitin-related modiﬁer (SUMOylation) and redox modifications plays an important role in ABA signaling. This review focused on the role of modifications in the core ABA signaling pathway.

Key words: ABA, phosphorylation, PTMs, redox, SUMOylation, ubiquitination

张静,侯岁稳. 蛋白质翻译后修饰在ABA信号转导中的作用. 植物学报, 2019, 54(3): 300-315.

Jing Zhang,Suiwen Hou. Role of Post-translational Modification of Proteins in ABA Signaling Transduction. Chinese Bulletin of Botany, 2019, 54(3): 300-315.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB18217

https://www.chinbullbotany.com/CN/Y2019/V54/I3/300

图/表 2

图1 磷酸化修饰在ABA信号中的作用 ABA的转运由运输载体如AtABCGs完成, 其转导途径由受体RCAR/PYR/PYLs、磷酸酶PP2Cs、激酶SnRK2s以及SnRK2s的底物等组成。转录因子(AREBs和HAT1)、膜蛋白(SLAC1、KAT1和NADPH氧化酶)、DNA解旋酶BRM、TOR激酶复合体和APC/C泛素复合体被SnRK2s磷酸化, 其中AREBs、BRM和SLAC1被PP2Cs去磷酸化。激酶BIN2是整合BR信号通路和ABA信号通路的关键因子。TOR激酶复合体与ABA信号相互拮抗调节植物生长与逆境响应。钙调激酶CPK23独立于SnRK2s参与气孔运动。激酶CARK1和AEL1磷酸化ABA受体PYR1的不同位点引起相反结果。绿色箭头表示促进作用; 红色T型线表示抑制作用。PM: 细胞膜; P: 磷酸化; Ub: 泛素化; A-: 阴离子; ROS: 活性氧; TR: 转录调控

Figure 1 The regulatory roles of protein phosphorylation in coreABA signaling ABA transport is performed by transporters, such as AtABCGs. The core ABA signaling pathway is composed of RCAR/PYR/PYLs, PP2Cs, SnRK2s, and the substrates of SnRK2s. The substrates of SnRK2s include AREBs, HAT1, SLAC1, KAT1, NADPH oxidases, BRM, TOR complex, and APC/C complex. AREBs, BRM and SLAC1 can be dephosphorylated by PP2Cs. BIN2 is a key factor that integrates BR and ABA signaling pathway. The TOR complex and ABA signaling antagonistically regulates plant growth and stress response. CPK23 is independent of SnRK2s in stomatal movement. Different phosphorylation sites of ABA receptor PYR1 by CARK1 and AEL1 give opposite results. Green arrows represent promotion; Red T-shaped bars represent repression. PM: Plasma membrane; P: Phosphorylation; Ub: Ubiquitination; A-: Negative ions; ROS: Reactive oxygen species; TR: Transcriptional regulation

图2 蛋白泛素化和SUMO化修饰调节ABA合成代谢、识别、转导和响应AAO3和CYP707A分别是ABA的合成酶和氧化酶。ABA中心转导途径由RCAR/PYR/PYLs-PP2Cs-SnRK2s-bZIPs组成。图中bZIPs代表OsBZIP23、ABF3、ABF1和ABI5 (绿色背景方框内)。红色背景中蛋白是ABA信号的负调节因子; 绿色背景中蛋白是ABA信号的正调节因子。箭头表示促进作用; T型线表示抑制作用; 实线表示有直接的互作关系; 虚线和?表示具体过程未知。+/-P: 磷酸化/去磷酸化; +U: 泛素化; +/-S: SUMO/去SUMO化; TR: 转录调控

Figure 2 Protein ubiquitination and sumoylation regulate ABA biosynthesis and catabolism, ABA perception, signal transduction and responsesAAO3 and CYP707A are ABA synthase and oxidase enzyme, respectively. The core ABA signaling pathway is composed of RCAR/PYR/PYLs-PP2Cs-SnRK2s-bZIPs. In this figure, bZIPs represent OsBZIP23, ABF3, ABF1 and ABI5 (inside the box on the green background). The proteins in the red (green) background are negative (positive) factors in ABA signaling. Arrows represent promotion; T-shaped bars represent repression; The solid line indicates direct interaction; Dotted lines and ? represent uncon?rmed. +/-P: Phosphorylation/dephosphorylation; +U: Ubiquitination; +/-S: SUMOylation/de-SUMOylation; TR: Transcriptional regulation

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