Chin Bull Bot ›› 2017, Vol. 52 ›› Issue (6): 681-684.doi: 10.11983/CBB17177

• COMMENTARY •     Next Articles

The Molecular Mechanism of Nitric Oxide-mediated S-nitrosylation Coordinating with Protein Methylation During Abiotic Stress Responses

Wang Yu, He Yikun*()   

  1. College of Life Sciences, Capital Normal University, Beijing 100048, China
  • Received:2017-09-20 Accepted:2017-11-02 Online:2018-12-10 Published:2017-11-01
  • Contact: He Yikun E-mail:yhe@cnu.edu.cn

Abstract:

Nitric oxide, as a small active particle, is involved in many physiological activities of animals and plants. In protein posttranslational modifications, NO is mainly in the form of (NO)-based S-nitrosylation. Methylation, as another protein transcription modification, also has an important role in DNA damage and mRNA translation. Although these two areas have many published articles in recent years, there are few reports of the interaction between the two approaches. Recently, Chinese scientists have found that NO can positively regulate the activity of PRMT5, an enzyme that catalyzes Arg symmetric demethylation, through S-nitrosylation at Cys-125. The Arabidopsis prmt5-1 mutant shows severe deve- lopmental defects and hypersensitivity in stress responses. A PRMT5C125S transgene with non-nitrosylatable mutation at Cys-125 in a prmt5-1 background shows recovered developmental defects but not the stress responses. Furthermore, S-nitrosylation at Cys-125 of PRMT5 was found involved in regulating Arg symmetric demethylation induced by NaCl. The study led to a new direction of protein S-nitrosylation and protein methylation modification, which opened up new research fields and set a new example for research in this field.

Key words: Arabidopsis, protein posttranscriptional modification, nitric oxide, S-nitrosylation, protein methylation

Figure 1

The reactions of S-nitrosylation"

Figure 2

The working model of protein S-nitrosylation coordinating with protein methylation during stress in plants (Hu et al., 2017)"

[1] Astier J, Rasul S, Koen E, Manzoor H, Besson-Bard A, Lamotte O, Jeandroz S, Durner J, Lindermayr C, Wendehenne D (2011). S-nitrosylation: an emerging post- translational protein modification in plants.Plant Sci 181, 527-533.
doi: 10.1016/j.plantsci.2011.02.011 pmid: 21893248
[2] Bedford MT, Clarke SG (2009). Protein arginine methylation in mammals: who, what, and why.Mol Cell 33, 1-13.
doi: 10.1016/j.molcel.2008.12.013 pmid: 19150423
[3] Chen RQ, Sun SL, Wang C, Li YS, Liang Y, An FY, Li C, Dong HL, Yang XH, Zhang J, Zuo JR (2009). The Arabidopsis PARAQUAT RESISTANT2 gene encodes an S-nitrosoglutathione reductase that is a key regulator of cell death. Cell Res 19, 1377-1387.
[4] Feechan A, Kwon E, Yun BW, Wang YQ, Pallas JA, Loake GJ (2005). A central role for S-nitrosothiols in plant disease resistance. Proc Natl Acad Sci USA 102, 8054-8059.
[5] Frungillo L, Spoel SH (2017). Modulating the modulator: regulation of protein methylation by nitric oxide.Mol Cell 67, 535-537.
doi: 10.1016/j.molcel.2017.08.001 pmid: 28820964
[6] Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS (2005). Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 6, 150-166.
[7] Hu JL, Yang HJ, Mu JY, Lu TC, Peng JL, Deng X, Kong ZS, Bao SL, Cao XF, Zuo JR (2017). Nitric oxide regulates protein methylation during stress responses in plants.Mol Cell 67, 702-710.
doi: 10.1016/j.molcel.2017.06.031 pmid: 28757206
[8] Tada Y, Spoel SH, Pajerowska-Mukhtar K, Mou ZL, Song JQ, Wang C, Zuo JR, Dong XN (2008). Plant immunity requires conformational charges of NPR1 via S-nitrosy- lation and thioredoxins. Science 321, 952-956.
[9] Tavares CP, Vernal J, Delena RA, Lamattina L, Cassia R, Terenzi H (2014). S-nitrosylation influences the structure and DNA binding activity of AtMYB30 transcription factor from Arabidopsis thaliana. Biochim Biophys Acta 1844, 810-817.
doi: 10.1016/j.bbapap.2014.02.015 pmid: 24583075
[10] Wang PC, Du YY, Hou YJ, Zhao Y, Hsu CC, Yuan FJ, Zhu XH, Tao WA, Song CP, Zhu JK (2015). Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proc Natl Acad Sci USA 112, 613-618.
[11] Yang HJ, Mu JY, Chen LC, Feng J, Hu JL, Li L, Zhou JM, Zuo JR (2015). S-nitrosylation positively regulates ascor- bate peroxidase activity during plant stress responses. Plant Physiol 167, 1604-1615.
[1] He Zhenmei,Li Dongming,Qi Yanhua. Advances in Biofunctions of the ABCB Subfamily in Plants [J]. Chin Bull Bot, 2019, 54(6): 688-698.
[2] Xu Wanyue, Wang Yingxiang. Chromosome Behaviors of Male Meiocytes by Chromosome Spread in Arabidopsis thaliana [J]. Chin Bull Bot, 2019, 54(5): 620-624.
[3] Chen Lichao, Zhan Ni, Li Yansha, Feng Jian, Zuo Jianru. Detection and Analysis of Protein S-nitrosylation in Plants [J]. Chin Bull Bot, 2019, 54(4): 497-502.
[4] Cui Shengnan, Zhang Yihan, Xu Fan. Heterologous Overexpression of Rice OsSAPP3 Gene Promotes Leaf Senescence in Transgenic Arabidopsis [J]. Chin Bull Bot, 2019, 54(1): 46-57.
[5] Liu Kaige, Qi Shuanghui, Duan Shaowei, Li Dong, Jin Changyu, Gao Chenhao, Liu Mingxun Chen Xuanxia. Functional Analysis of Brassica napus BnTTG1-1 Gene [J]. Chin Bull Bot, 2017, 52(6): 713-722.
[6] Shengchun Zhang, Qingming Li, Chengwei Yang. Arabidopsis Metalloprotease FtSH4 Regulates Leaf Senescence Through Auxin and Reactive Oxygen Species [J]. Chin Bull Bot, 2017, 52(4): 453-464.
[7] Lingling Zhang, Dan Wu, Zijie Zhao, Liqun Zhao. Research Progress in Nitric Oxide Signaling Molecule in Plants [J]. Chin Bull Bot, 2017, 52(3): 337-345.
[8] Mingjie He, Yichen Sun, Xiaoyuan Cheng, Dongxue Shi, Diqin Li, Yiyin Chen, Yongkun Feng, Lu Liu, Tengfei Fan, Chao Yang, Fengqiu Cao, Laihua Liu. Current Research Advances on Glutamate Receptors (GLRs) in Plants [J]. Chin Bull Bot, 2016, 51(6): 827-840.
[9] Juqing Kang, Tianshu Sun, Huiting Zhang, Yihao Shi. Quantitative Trait Loci Mapping Platform of Natural Populations of Arabidopsis thaliana along the Yangtze River in China [J]. Chin Bull Bot, 2016, 51(5): 659-666.
[10] Juqing Kang, Daipeng Zhang. Association of CBF3 Expression and ROS Content Under Low Temperature among Natural Populations of Arabidopsis thaliana in China [J]. Chin Bull Bot, 2016, 51(5): 577-585.
[11] Chunli Ma, Mailisi HeShuote, Zhi Qi, Jing Wang, Junxia Zhang. Mg2+ Transporter MGT7 Mediates Arabidopsis thaliana Adapting to High Calcium Environment [J]. Chin Bull Bot, 2016, 51(4): 496-503.
[12] Hongmei Xi, Wenzhong Xu, Mi Ma. Advances in Biological Function of Arabidopsis Bifunctional Enzyme SAL1 [J]. Chin Bull Bot, 2016, 51(3): 377-386.
[13] Hui Liu, Danli Guo, Darun Cai, Xianzhong Huang. Heterologous overexpression of ApZFP Promotes Flowering and Improves Abiotic Tolerance in Arabidopsis thaliana [J]. Chin Bull Bot, 2016, 51(3): 296-305.
[14] Kaijian Lei, Jing Ren, Yuanyuan Zhu, Guoyong An. SPL1 is Involved in the Regulation of Rhizosphere Acidification Reaction Under Low Phosphate Condition in Arabidopsis [J]. Chin Bull Bot, 2016, 51(2): 184-193.
[15] Xiongbo Peng, Meng-Xiang Sun. Chinese Scientists Made Breakthrough Progresses in Studies on Signaling Between Male and Female Gametophytes During Fertilization in Plants [J]. Chin Bull Bot, 2016, 51(2): 145-147.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Chin Bull Bot, 1994, 11(专辑): 19 .
[2] Xiao Xiao and Cheng Zhen-qi. Chloroplast 4.5 S ribosomol DNA. II Gene and Origin[J]. Chin Bull Bot, 1985, 3(06): 7 -9 .
[3] CAO Cui-LingLI Sheng-Xiu. Effect of Nitrogen Level on the Photosynthetic Rate, NR Activity and the Contents of Nucleic Acid of Wheat Leaf in the Stage of Reproduction[J]. Chin Bull Bot, 2003, 20(03): 319 -324 .
[4] SONG Li-Ying TAN Zheng GAO Feng DENG Shu-Yan. Advances in in vitro Culture of Cucurbitaceae in China[J]. Chin Bull Bot, 2004, 21(03): 360 -366 .
[5] Shi Jian ming;Gui Yao-lin and Zhu Zhi-qing. Observation on Amitosis of Sugarbeet (Beta vulgaris) Petiole during Dedifferentiation in Vitro[J]. Chin Bull Bot, 1989, 6(03): 155 .
[6] . [J]. Chin Bull Bot, 1994, 11(专辑): 76 .
[7] LI Jun-De YANG Jian WANG Yu-Fei. Aquatic Plants in the Miocene Shanwang Flora[J]. Chin Bull Bot, 2000, 17(专辑): 261 .
[8] XU Jing-Xian WANG Yu-Fei YANG Jian PU Guang-Rong ZHANG Cui-Fen. Advances in the Research of Tertiary Flora and Climate in Yunnan[J]. Chin Bull Bot, 2000, 17(专辑): 84 -94 .
[9] Sun Zhen-xiao Xia Guang-min Chen Hui-min. Karyotype Analysis of Psathyrostachys juncea[J]. Chin Bull Bot, 1995, 12(01): 56 .
[10] . [J]. Chin Bull Bot, 1994, 11(专辑): 8 -9 .