PPR蛋白参与细胞器RNA C→U编辑机制研究进展

doi:10.11983/CBB24085

植物学报 ›› 2024, Vol. 59 ›› Issue (6): 903-911.DOI: 10.11983/CBB24085 cstr: 32102.14.CBB24085

PPR蛋白参与细胞器RNA C→U编辑机制研究进展

于晓琳, 李西雅, 夏冰玉洁, 李昊, 谭保才, 王勇^*()

山东大学生命科学学院, 植物发育与环境适应生物学教育部重点实验室, 青岛 266237

收稿日期:2024-06-01 接受日期:2024-08-20 出版日期:2024-11-10 发布日期:2024-08-28
通讯作者: *王勇, 博士, 副研究员, 硕士生导师。其研究团队主要从事玉米种子发育关键基因克隆、功能解析和RNA加工机制研究, 系统解析了多个基因的功能, 并明确了这些基因参与细胞器RNA加工以及玉米种子发育的分子机制。相关成果以第一作者身份发表在Plant Cell、Plant Commun、PLoS Genet、Plant J和Front Plant Sci等学术期刊; 以合作者身份在Nat Commun、Proc Natl Acad Sci USA、New Phytol、Plant Physiol、J Integr Plant Biol和J Exp Bot等国际主流学术期刊发表论文10余篇。主持国家自然科学基金等项目多项。E-mail: wangy07@sdu.edu.cn
基金资助:
国家自然科学基金(32101640)

Research Advance of PPR Proteins Involved in the Mechanism of Organelle RNA C→U Editing

Xiaolin Yu, Xiya Li, Bingyujie Xia, Hao Li, Baocai Tan, Yong Wang^*()

Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China

Received:2024-06-01 Accepted:2024-08-20 Online:2024-11-10 Published:2024-08-28
Contact: *E-mail: wangy07@sdu.edu.cn

1. 附录.pdf(615KB)

摘要/Abstract

摘要： 植物体中线粒体和叶绿体是半自主细胞器, 具有自己的基因组。RNA编辑对于细胞器基因的正确表达至关重要, 最常见的RNA编辑是C→U。RNA C→U编辑需要多种编辑因子参与, 其中PPR蛋白中的PPR基序阵列特异性地靶向编辑位点, PPR-DYW蛋白DYW结构域是催化C→U编辑的脱氨酶。该文综述了PPR蛋白参与RNA C→U编辑机制的最新研究进展, 并讨论了人工合成PPR编辑因子的潜在应用价值。

关键词: PPR蛋白, RNA C→U编辑, 线粒体, 叶绿体

Abstract: Mitochondria and chloroplasts are semi-autonomous organelles harboring their own genomes. RNA editing is essential for the correct expression of organelle genes. The mostly identified RNA editing is cytidine (C)-to-uridine (U). Multiple editing factors have been reported to be involved in RNA C→U editing. The PPR-motifs array in PPR proteins specifically target editing sites, and the DYW domains in PPR-DYW proteins catalyze the deaminase in the C→U editing. This paper aims to review the recent advance of PPR proteins involved in RNA C→U editing, and to discuss the potential application value of synthetic PPR editing factors.

Key words: PPR proteins, RNA C→U editing, mitochondria, chloroplasts

于晓琳, 李西雅, 夏冰玉洁, 李昊, 谭保才, 王勇. PPR蛋白参与细胞器RNA C→U编辑机制研究进展. 植物学报, 2024, 59(6): 903-911.

Xiaolin Yu, Xiya Li, Bingyujie Xia, Hao Li, Baocai Tan, Yong Wang. Research Advance of PPR Proteins Involved in the Mechanism of Organelle RNA C→U Editing. Chinese Bulletin of Botany, 2024, 59(6): 903-911.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB24085

https://www.chinbullbotany.com/CN/Y2024/V59/I6/903

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PPR蛋白参与细胞器RNA C→U编辑机制研究进展

Research Advance of PPR Proteins Involved in the Mechanism of Organelle RNA C→U Editing

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