Chinese Bulletin of Botany ›› 2021, Vol. 56 ›› Issue (2): 142-146.DOI: 10.11983/CBB21042

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Synergistic Cooperation Between Cell Surface and Intracellular Immune Receptors Potentiates to Activate Robust Plant Defense

Wei Wang, Dingzhong Tang()   

  1. Plant Immunity Center, Fujian Agriculture and Forestry University, Fuzhou 350002, China
  • Received:2021-03-02 Accepted:2021-03-05 Online:2021-03-01 Published:2021-03-17
  • Contact: Dingzhong Tang

Abstract: Innate immune system plays a crucial role to defend against pathogens attack and is classified into two layers, which include pathogen-associated molecular pattern-triggered immunity (PTI) and effector-triggered immunity (ETI). The PTI and ETI are activated by cell-surface localized pattern-recognition receptors (PRRs) and mostly intracellularly-localized nucleotide-binding, leucine-rich repeat receptors (NLRs), respectively, with specific activation mechanisms, but largely overlapped downstream immune events and components. One of the top unanswered questions in the field of plant immunity is whether ETI and PTI are really distinct, considering the high similarity of the downstream of the recognition processes and components. Recently, a team led by Prof. Xiufang Xin, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, used the Arabidopsis thaliana and Pseudomonas syringae pathosystem to study the functional link between PTI and ETI, and demonstrated that PRRs and the co-receptor of PRRs contribute to ETI, and the production of reactive oxygen species (ROS) is the early signal event that connects PTI and ETI. They also showed that ETI enhances the transcript and protein levels of key components of PTI, and the increased PTI is crucial for full activation of ETI. This study provides mechanistic explanation to a long-lasting enigma in the field of plant immunity regarding the mechanistic connections of PTI and ETI, and the high similarity of these two layers of immunity. This work represents an important breakthrough in the field of plant immunity, and will have implications for the future molecular breeding in crops.

Key words: plant immunity, pattern-triggered immunity (PTI), effector-triggered immunity (ETI), reactive oxygen species, nucleotide-binding site and leucine-rich repeat domain receptors (NLRs), pattern-recognition receptors (PRRs)