Chinese Bulletin of Botany ›› 2019, Vol. 54 ›› Issue (3): 288-292.DOI: 10.11983/CBB19035
Special Issue: 逆境生物学专辑
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Received:
2019-02-23
Accepted:
2019-04-03
Online:
2019-07-01
Published:
2019-05-20
Contact:
Shitou Xia,Xin Li
Shitou Xia,Xin Li. Open a Door of Defenses: Plant Resistosome[J]. Chinese Bulletin of Botany, 2019, 54(3): 288-292.
Figure 1 PBL2UMP-induced activation and assembly of the ZAR1 resistosome Arabidopsis PBL2 is modified by uridylyl transferase AvrAC, which is an effector protein from Xanthomonas campestris. The uridylylated PBL2 (PBL2UMP) as a ligand is then recruited by the ZAR1-RKS1 complex through interaction with the pseudokinase RKS1. The activation segment of RKS1 becomes stabilized (orange surface) after interacting with the two uridylyl moieties (in sphere) of PBL2UMP, and sterically clashes with ZAR1NBD, causing the latter to rotate outward and consequently release ADP, forming an intermediate ZAR1-RKS1-PBL2UMP complex which allows it to bind dATP/ATP. Binding of dATP/ATP induces structural remodeling and fold switching of ZAR1. The very N-terminal helix (α1, red) of ZAR1 buried in the inactive ZAR1-RKS1 complex becomes solvent-exposed in the activated ZAR1-RKS1-PBL2UMP complex, forming a ZAR1 resistosome pentameric structure through polymerization (a funnel-shaped structure highlighted within the purple frame). CC, NBD, HD1, WHD and LRR are different structural domains of ZAR1.
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