Advances in Plant Flavonoid Transport and Accumulation Mechanism

doi:10.11983/CBB23066

Abstract

Abstract: Flavonoids are polyphenols compounds produced during the secondary metabolism of plants, which are widely present in plants and have various functions. Flavonoids biosynthesis takes place at the cytosolic side of the en- doplasmic reticulum (ER), but accumulation of various flavonoids is observed in the vacuole. Efficient transport and ac- cumulation systems are therefore required to transfer flavonoids from the ER into the vacuole. Certain researches for the transport of flavonoids has been done for decades. Current research results showed that: there are three transport mechanisms in plants, including glutathione S-transferase (GST), membrane transporters, and vesicle trafficking. Here, we reviewed the three transport mechanisms and advances of plant flavonoids transport in recent years. The functional cooperation of three distinct but nonexclusive mechanisms were summarized. While the biosynthesis of the flavonoids is well characterized across species, the research on flavonoids transport and accumulation is still relatively insufficient. For better understand the flavonoids transport and accumulation mechanism in plant, the relationship between flavonoids modification and transport, flavonoids transport substrate specificity and preference, and transcriptional regulation of flavonoids transport remain deeply unexplored.

Key words: flavonoid, transport, glutathione S-transferase, membrane transporter, vesicle trafficking

Jingwen Xie, Xiaoyun Cao, Wanqi Pan, Lingjuan Du. Advances in Plant Flavonoid Transport and Accumulation Mechanism[J]. Chinese Bulletin of Botany, 2024, 59(3): 463-480.

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URL: https://www.chinbullbotany.com/EN/10.11983/CBB23066

https://www.chinbullbotany.com/EN/Y2024/V59/I3/463

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物种	基因	GenBank登录号	参考文献
玉米(Zea mays)	Bronze2	AAA50245	Marrs et al., 1995
矮牵牛(Petunia hybrida)	PhAN9	CAA68993	Alfenito et al., 1998
拟南芥(Arabidopsis thaliana)	AtTT19	BAD89984	Kitamura et al., 2004
葡萄(Vitis vinifera)	VvGST1	AY156048	Conn et al., 2008
	VvGST4	AY971515	Pérez-Díaz et al., 2016
紫苏(Perilla frutescens)	PfGST1	AB362191	Yamazaki et al., 2008
仙客来(Cyclamen persicum)	CkmGST3	AB682678	Kitamura et al., 2012
香石竹(Dianthus caryophyllus)	FL3/DcGSTF2	AB688111	Sasaki et al., 2012
瓜叶菊(Pericallis × hybrida=Senecio cruentus)	ScGST3		Cui et al., 2021
中华猕猴桃(Actinidia chinensis)	AcGST1	MK238757	Liu et al., 2019
桃(Prunus persica)	PpGST1和Riant	ALE31199	Cheng et al., 2015
	PpGST1		Zhao et al., 2020
苹果(Malus pumila=Malus domestica)	MdGSTF6		Jiang et al., 2019
番薯(Ipomoea batatas)	IbGSTF4	MG873448	Kou et al., 2019
荔枝(Litchi chinensis)	LcGST4	ALY05893	Hu et al., 2016a
野草莓(Fragaria vesca)	FvRAP	XP_004288578	Luo et al., 2018
茶(Camellia sinensis)	CsGSTF1		Wei et al., 2019
一品红(Euphorbia pulcherrima)	Bract1	MW718861	Vilperte et al., 2021
萝卜(Raphanus sativus)	RsGST1		Lai et al., 2021
	RsGSTF12		Niu et al., 2022
百合(Lilium brownii var. viridulum)	LhGST	MK426728	Cao et al., 2021
陆地棉(Gossypium hirsutum)	GhGSTF12		Shao et al., 2021
	GhTT19		Chai et al., 2023
蒺藜苜蓿(Medicago truncatula)	MtGSTF7		Wang et al., 2022b
西洋梨(Pyrus communis)	PcGSTF12		Zhang et al., 2020
欧洲甜樱桃(Prunus avium)	PavGST1		Qi et al., 2022
杨梅(Morella rubra)	MrGST1		Xue et al., 2022
牡丹(Paeonia × suffruticosa)	PsGSTF3		Han et al., 2022

物种	基因	GenBank登录号	参考文献
玉米(Zea mays)	Bronze2	AAA50245	Marrs et al., 1995
矮牵牛(Petunia hybrida)	PhAN9	CAA68993	Alfenito et al., 1998
拟南芥(Arabidopsis thaliana)	AtTT19	BAD89984	Kitamura et al., 2004
葡萄(Vitis vinifera)	VvGST1	AY156048	Conn et al., 2008
	VvGST4	AY971515	Pérez-Díaz et al., 2016
紫苏(Perilla frutescens)	PfGST1	AB362191	Yamazaki et al., 2008
仙客来(Cyclamen persicum)	CkmGST3	AB682678	Kitamura et al., 2012
香石竹(Dianthus caryophyllus)	FL3/DcGSTF2	AB688111	Sasaki et al., 2012
瓜叶菊(Pericallis × hybrida=Senecio cruentus)	ScGST3		Cui et al., 2021
中华猕猴桃(Actinidia chinensis)	AcGST1	MK238757	Liu et al., 2019
桃(Prunus persica)	PpGST1和Riant	ALE31199	Cheng et al., 2015
	PpGST1		Zhao et al., 2020
苹果(Malus pumila=Malus domestica)	MdGSTF6		Jiang et al., 2019
番薯(Ipomoea batatas)	IbGSTF4	MG873448	Kou et al., 2019
荔枝(Litchi chinensis)	LcGST4	ALY05893	Hu et al., 2016a
野草莓(Fragaria vesca)	FvRAP	XP_004288578	Luo et al., 2018
茶(Camellia sinensis)	CsGSTF1		Wei et al., 2019
一品红(Euphorbia pulcherrima)	Bract1	MW718861	Vilperte et al., 2021
萝卜(Raphanus sativus)	RsGST1		Lai et al., 2021
	RsGSTF12		Niu et al., 2022
百合(Lilium brownii var. viridulum)	LhGST	MK426728	Cao et al., 2021
陆地棉(Gossypium hirsutum)	GhGSTF12		Shao et al., 2021
	GhTT19		Chai et al., 2023
蒺藜苜蓿(Medicago truncatula)	MtGSTF7		Wang et al., 2022b
西洋梨(Pyrus communis)	PcGSTF12		Zhang et al., 2020
欧洲甜樱桃(Prunus avium)	PavGST1		Qi et al., 2022
杨梅(Morella rubra)	MrGST1		Xue et al., 2022
牡丹(Paeonia × suffruticosa)	PsGSTF3		Han et al., 2022

物种	基因	GenBank登录号	参考文献
拟南芥(Arabidopsis thaliana)	AtTT12	AJ294464	Debeaujon et al., 2001
	FFT (AtDTX35)	F4JTB3	Kitamura et al., 2016
蒺藜苜蓿(Medicago truncatula)	MtMATE1	ACX37118	Zhao and Dixon, 2009
	MtMATE2	ADV04045	Zhao et al., 2011
苹果(Malus pumila=Malus domestica)	MdMATE1	ADO22709	Frank et al., 2011
	MdMATE2	ADO22711	Frank et al., 2011
葡萄(Vitis vinifera)	VvAM1	ACN91542	Gomez et al., 2009
	VvAM3	ACN88706	Gomez et al., 2009
百合(Lilium brownii var. viridulum)	LhDTX35	MT001433	Xu et al., 2020
草莓(Fragaria × ananassa)	FaTT12-1	KY851294	Chen et al., 2018
陆地棉(Gossypium hirsutum)	GhTT12	KF240564	Gao et al., 2016
番茄(Solanum lycopersicum)	SlMATE/MTP77	AAQ55183	Mathews et al., 2003
柿(Diospyros kaki)	DkMATE1		Yang et al., 2016
鹰嘴豆(Cicer arietinum)	CaMATE1		Pal et al., 2023
克里曼丁橘(Citrus clementina)	CitMATE43		Liu et al., 2022
矮牵牛(Petunia hybrida)	PhMATE1		Yuan et al., 2023
白梨(Pyrus bretschneideri)	PbTT12		刘汉婷, 2020
烟草(Nicotiana tabacum)	NtMATE21		Gani et al., 2022
	NtMATE22		Gani et al., 2022
大豆(Glycine max)	GmMATE1		Ng et al., 2021
	GmMATE4		Ku et al., 2022

物种	基因	GenBank登录号	参考文献
拟南芥(Arabidopsis thaliana)	AtTT12	AJ294464	Debeaujon et al., 2001
	FFT (AtDTX35)	F4JTB3	Kitamura et al., 2016
蒺藜苜蓿(Medicago truncatula)	MtMATE1	ACX37118	Zhao and Dixon, 2009
	MtMATE2	ADV04045	Zhao et al., 2011
苹果(Malus pumila=Malus domestica)	MdMATE1	ADO22709	Frank et al., 2011
	MdMATE2	ADO22711	Frank et al., 2011
葡萄(Vitis vinifera)	VvAM1	ACN91542	Gomez et al., 2009
	VvAM3	ACN88706	Gomez et al., 2009
百合(Lilium brownii var. viridulum)	LhDTX35	MT001433	Xu et al., 2020
草莓(Fragaria × ananassa)	FaTT12-1	KY851294	Chen et al., 2018
陆地棉(Gossypium hirsutum)	GhTT12	KF240564	Gao et al., 2016
番茄(Solanum lycopersicum)	SlMATE/MTP77	AAQ55183	Mathews et al., 2003
柿(Diospyros kaki)	DkMATE1		Yang et al., 2016
鹰嘴豆(Cicer arietinum)	CaMATE1		Pal et al., 2023
克里曼丁橘(Citrus clementina)	CitMATE43		Liu et al., 2022
矮牵牛(Petunia hybrida)	PhMATE1		Yuan et al., 2023
白梨(Pyrus bretschneideri)	PbTT12		刘汉婷, 2020
烟草(Nicotiana tabacum)	NtMATE21		Gani et al., 2022
	NtMATE22		Gani et al., 2022
大豆(Glycine max)	GmMATE1		Ng et al., 2021
	GmMATE4		Ku et al., 2022

物种	基因	GenBank登录号	参考文献
玉米(Zea mays)	ZmMRP3	AY609318	Goodman et al., 2004
	ZmMRP4	BG349642	Goodman et al., 2004
拟南芥(Arabidopsis thaliana)	AtABCC2	NP_001189675	Behrens et al., 2019
葡萄(Vitis vinifera)	VvABCC1	JX245004	Francisco et al., 2013
水稻(Oryza sativa)	OsMRP15	LOC_Os06g06440	Zhu et al., 2013
桃(Prunus persica)	PpABCC1		Sylvia et al., 2023
拟南芥(A. thaliana)	AtABCC1、AtABCC2和AtABCC14		Dean et al., 2022