网格蛋白介导的胞吞作用(clathrin-mediated endocytosis, CME)是动植物细胞中质膜蛋白进行胞吞的主要途径之一, 网格蛋白及其接头蛋白复合体介导的胞吞作用在植物形态建成、根尖向地性生长、避盐反应、免疫响应、营养元素运输等过程中发挥重要作用。本文以动物细胞网格蛋白及其介导的胞吞作用为基础, 阐述植物网格蛋白及其接头蛋白复合体的组成、定位和生物学功能, 并系统总结了植物CME途径在调控植物生长发育和应对生物与非生物胁迫等生物学过程中的重要作用, 同时对其未来研究方向进行展望, 旨在为深入研究植物CME途径的分子机理提供参考。

Clathrin-mediated endocytosis (CME) is one of the primary pathways for the internalization of plasma membrane proteins in animal and plant cells. Clathrin and its adaptor protein complexes play crucial roles in plant morphogenesis, root gravitropic growth, halotropism response, immune signaling and nutrient elements. This review begins with an overview of clathrin and its mediated endocytosis in animal cells, briefly summarizing the composition, localization, and biological functions of plant clathrin and its adaptor protein complexes. It focuses on the regulatory mechanisms and biological roles of the CME pathway in plants, while also summarizing and prospecting the critical contributions of CME to plant growth, development, and responses to biotic and abiotic stresses. Furthermore, future research directions are discussed, providing valuable references for ‌in-depth exploration‌ of the ‌molecular mechanisms‌ underlying the plant CME pathway.