植物学报 ›› 2012, Vol. 47 ›› Issue (6): 571-580.DOI: 10.3724/SP.J.1259.2012.00571

• 特邀综述 • 上一篇    下一篇

利用异源生物生产青蒿素及其前体的研究进展

李星1, 郝鹤1, 池剑亭1, 王红1*, 叶和春2   

  1. 1中国科学院大学生命科学学院, 北京 100049;
    2中国科学院植物研究所, 北京 100093
  • 收稿日期:2012-03-05 修回日期:2012-04-27 出版日期:2012-11-01 发布日期:2012-09-04
  • 通讯作者: 王红
  • 基金资助:

    中国科学院“十二五”基础前沿专项

An Overview of Heterologous Organisms Used to Produce Artemisinin and Its Precursors

Xing Li1, He Hao1, Jianting Chi1, Hong Wang1*, Hechun Ye2   

  1. 1College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China;

    2Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
  • Received:2012-03-05 Revised:2012-04-27 Online:2012-11-01 Published:2012-09-04
  • Contact: Hong Wang

摘要: 青蒿素是从中药青蒿中分离出来的一种倍半萜内酯类化合物, 也是目前最有效的抗疟疾药物, 对人类健康意义重大。该文通过对青蒿素生物合成途径及其相关酶的介绍, 综述了利用异源生物通过组合生物合成途径生产青蒿素及其前体的最新研究进展。

Abstract: Artemisinin, a sesquiterpene endoperoxide lactone extracted from the traditional Chinese herb Artemisia annua, is an effective drug against the malaria parasite Plasmodium falciparum and has many positive effects on human health. We explored the possibility of producing artemisinin and its precursors by heterologous systems including Escherichia coli, Sacchromyces cerevisiae and tobacco. We also discuss recent progress in the artemisinin biosynthetic pathway and new genes and enzymes involved in artemisinin biosynthesis.