植物学报 ›› 2008, Vol. 25 ›› Issue (02): 149-160.

• 综述 • 上一篇    下一篇

着丝粒结构与功能研究的新进展

丁戈1, 姚南2, 吴琼1, 刘恒1* , 郑国锠1   

  1. 1 兰州大学生命科学学院细胞生物学研究所, 兰州 730000; 2 兰州大学第一医院, 兰州 730000
  • 收稿日期:2007-08-14 修回日期:2007-11-07 出版日期:2008-03-01 发布日期:2008-03-01
  • 通讯作者: 刘恒

Research Progress on the Structure and Function of Centromeres

Ge Ding1, Nan Yao2, Qiong Wu1, Heng Liu1*, Guochang Zheng1   

  1. 1Institute of Cell Biology, College of Life Science, Lanzhou University, Lanzhou 730000, China; 2First Hospital, Lanzhou University, Lanzhou 730000, China
  • Received:2007-08-14 Revised:2007-11-07 Online:2008-03-01 Published:2008-03-01
  • Contact: Liu Heng

摘要: 着丝粒是真核生物染色体的显著特征。在细胞有丝分裂和减数分裂中, 着丝粒作为保证染色体正常分裂并分离到子细胞的结构和功能元件, 参与了同源染色体配对、姐妹染色单体黏合、分离及分裂后期启动的调控等。本文对近年来着丝粒结构和功能研究的新进展进行了概述。

Abstract: As the remarkable characteristic of every eukaryotic chromosome, the centromere is the structural and functional element that ensures the normal split and separation of chromosomes during mitosis and meiosis. It is involved in processes such as homologous chromosome pairing, sister chromatid adhesion and separation, and some of the regulation initiated during anaphase. Here we review some of recent progress in research into the structure and function of centromeres.