植物HIPP家族蛋白结构和功能研究进展

doi:10.11983/CBB23112

植物学报 ›› 2024, Vol. 59 ›› Issue (4): 659-670.DOI: 10.11983/CBB23112 cstr: 32102.14.CBB23112

植物HIPP家族蛋白结构和功能研究进展

张雅琦¹^,², 戎福喜², 沈雨欣², 洪哲源¹^,², 张蓝天¹^,², 武亮¹^,²^,^*()

¹浙江大学海南研究院, 三亚 572025
²浙江大学农业与生物技术学院, 杭州 310000

收稿日期:2023-08-17 接受日期:2023-11-02 出版日期:2024-07-10 发布日期:2024-07-10
通讯作者: *武亮, 浙江大学长聘教授, 博士生导师, 主要从事作物非编码RNA、开花期调控、功能基因组学方面研究。曾主持国家自然科学基金重大研究计划和面上项目、浙江省杰出青年基金、浙江省自然科学基金等重点科研项目。近年来在Nature Communications、The Plant Cell、Molecular Plant和Science China-Life Sciences等著名期刊上发表论文多篇, 培养了包括浙江省杰出青年基金获得者和博新计划入选者在内的多名优秀青年科技人才。E-mail: liangwu@zju.edu.cn
基金资助:
三亚市科技创新专项(2022KJCX48);海南专项博士研究生科学研究基金(0201-6602-C22201);海南专项博士研究生科学研究基金(0201-6602-C22202)

Research Advances of Structure and Function of HIPP Family in Plants

Yaqi Zhang¹^,², Fuxi Rong², Yuxin Shen², Zheyuan Hong¹^,², Lantian Zhang¹^,², Liang Wu¹^,²^,^*()

¹Hainan Institute of Zhejiang University, Sanya 572025, China
²College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310000, China

Received:2023-08-17 Accepted:2023-11-02 Online:2024-07-10 Published:2024-07-10
Contact: ^*E-mail: liangwu@zju.edu.cn

摘要/Abstract

摘要： 重金属相关异戊二烯化植物蛋白HIPP是一类含有金属结合结构域(HMA)和C端异戊二烯化基序的金属伴侣蛋白。该文总结了模式植物中HIPP蛋白的结构特征, 阐述了植物HIPP蛋白家族参与的重金属稳态和解毒机制, 揭示了其在植物生长发育和应对环境变化(生物和非生物胁迫)中的潜在意义, 以期为HIPP蛋白家族的后续研究提供启示。

关键词: HIPPs, HMA, 重金属

Abstract: Heavy metal-associated isoprenylated plant proteins (HIPPs) are a class of proteins characterized by the presence of heavy metal-associated domains (HMA) and C-terminal isoprenylation motifs in plants. Here, we introduce the structural characteristics of the HIPPs, review their potential roles in plant development and response to environmental changes (including biotic and abiotic stresses) as well as discuss their working mechanisms underlying their participation in heavy-metal homeostasis and detoxification. This comprehensive overview aims to provide valuable insights for future research on the HIPP family across diverse plant species.

Key words: HIPPs, HMA, heavy metals

张雅琦, 戎福喜, 沈雨欣, 洪哲源, 张蓝天, 武亮. 植物HIPP家族蛋白结构和功能研究进展. 植物学报, 2024, 59(4): 659-670.

Yaqi Zhang, Fuxi Rong, Yuxin Shen, Zheyuan Hong, Lantian Zhang, Liang Wu. Research Advances of Structure and Function of HIPP Family in Plants. Chinese Bulletin of Botany, 2024, 59(4): 659-670.

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链接本文: https://www.chinbullbotany.com/CN/10.11983/CBB23112

https://www.chinbullbotany.com/CN/Y2024/V59/I4/659

图/表 5

图1 拟南芥(A)和水稻(B)中HIPP家族蛋白的结构分析

Figure 1 Structural analysis of HIPP family in Arabidopsis (A) and rice (B)

图2 HIPP蛋白参与调控植物细胞内金属稳态重金属离子通过金属转运蛋白(如ZIPs和HMAs)进入细胞, 随后被细胞质中的HIPPs主动螯合, HIPP蛋白将金属离子运输至相应的靶蛋白处。对于过量或有毒金属离子, HIPPs一方面将其转运至质膜外排转运蛋白, 进行主动外排; 另一方面通过液泡膜转运蛋白(如HMAs)将其运送至液泡中隔离。

Figure 2 HIPPs are involved in the metal homeostasis regulation in plant cells Heavy metal ions enter the cells by metal transporters (such as ZIPs, and HMAs), which are actively chelated by HIPPs in the cytoplasm and then subsequently transported into target proteins. For excess or toxic metal ions, on the one hand, they can be actively transferred by HIPPs to the plasma membrane efflux transporters; on the other hand, they can be also isolated into the vacuole via vacuole membrane transporters (such as HMAs).

表1 植物体内HIPP基因具有维持重金属稳态和解毒的生物学功能

Table 1 Functions of HIPPs in maintaining heavy metal homeostasis and detoxification in plants

物种	基因	功能	参考文献
拟南芥 (Arabidopsis thaliana)	AtHIPP07	结合Cu²⁺、Ni²⁺和Zn²⁺; 耐受镉胁迫	Dykema et al., 1999
	AtHIPP06	结合Cu²⁺和Hg²⁺; 耐受镉胁迫	Suzuki et al., 2002
	AtHIPP26	结合Pb²⁺、Cd²⁺和Cu²⁺; 耐受镉胁迫	Gao et al., 2009
	AtHIPP20/21/22	突变体植株对镉敏感	Tehseen et al., 2010
	AtHIPP27	增强酵母镉胁迫的耐受性	Zhao et al., 2013
水稻 (Oryza sativa)	OsHIPP42	耐受镉胁迫	Khan et al., 2019
	OsHIPP28 OsHIPP34 OsHIPP60	响应Zn²⁺和Fe²⁺诱导表达	Khan et al., 2019
	OsHIPP29	耐受镉和锌胁迫	Zhang et al., 2020
	OsHIPP24	结合Cd²⁺和Cu²⁺; 酵母异源表达体系耐受镉胁迫	Chen and Xiong, 2021
	OsHIPP56	耐受镉和锌胁迫	Zhao et al., 2022
	OsHIPP16	耐受镉胁迫	Cao et al., 2022b
	OsHIPP33	维持水稻植株锌和铁稳态	Cao et al., 2022a
	OsHIPP9	结合Cd²⁺和Cu²⁺; 增强酵母镉胁迫的耐受性	Xiong et al., 2023
	OsHIPP17	降低酵母镉胁迫的耐受性	Shi et al., 2023
小麦 (Triticum aestivum)	TaHIPP1	增强酵母盐胁迫和铜胁迫的耐受性	Zhang et al., 2015

表2 已鉴定的HIPP在植物响应生物和非生物胁迫中的作用

Table 2 Roles of identified HIPPs in plant responses to biotic and abiotic stress

物种	基因	功能	参考文献
拟南芥 (Arabidopsis thaliana)	AtHIPP26	对干旱、盐和冷害胁迫转录响应; 与干旱胁迫相关转录因子AtHB29互作	Barth et al., 2009
	AtHIPP03	调控水杨酸依赖的病原菌应答途径	Zschiesche et al., 2015
	AtHIPP01	触发细胞分裂素氧化/脱氢酶CKX1的降解	Guo et al., 2021
水稻 (Oryza sativa)	OsHIPP09	对干旱胁迫转录响应	De Abreu-Neto et al., 2013
	OsHIPP23	对干旱胁迫转录响应	De Abreu-Neto et al., 2013
	OsHIPP40	对干旱胁迫转录响应	De Abreu-Neto et al., 2013
	OsHIPP11 OsHIPP45	对冷害胁迫转录响应	De Abreu-Neto et al., 2013
	OsHIPP41	对干旱和冷害胁迫转录响应	De Abreu-Neto et al., 2013
	OsHIPP05	促进水稻体内稻瘟病菌生长	Fukuoka et al., 2001
	OsHIPP04	与寄生线虫效应蛋白MgMO289互作, 抑制植物免疫	Song et al., 2001
	OsHIPP19	与稻瘟病菌效应蛋白AVR-Pik的所有变体互作, 激活植物免疫	Maidment et al., 2021
大麦 (Hordeum vulgare)	HvFP1	对干旱、盐和冷害胁迫转录响应	Barth et al., 2004
小麦 (Triticum aestivum)	TaHIPP1	对干旱、低温、强光、脱落酸胁迫和叶片衰老转录响应	Zhang et al., 2015
葡萄 (Vitis vinifera)	VvHIPP21	降低植株对低温和干旱胁迫的耐受性	Zheng et al., 2023
藜麦 (Chenopodium quinoa)	CqHIPP34	提高藜麦的耐旱性	Sun et al., 2022

图3 HIPP蛋白参与调控植物生物和非生物胁迫响应的工作模型植物响应环境胁迫信号(如光照、干旱、寒冷、盐胁迫和病原体攻击)后, 会触发HIPP基因的转录和翻译。对非生物胁迫而言, HIPP蛋白与下游靶蛋白互作, 从而激活干旱/冷害响应机制及水杨酸信号合成等植物抗逆反应通路, 最终调节植物对非生物胁迫的抗性或耐受性; 对生物胁迫而言, 目前鉴定到的多数HIPP蛋白与靶蛋白的结合则常发挥负调控作用, 抑制植物免疫, 加重感染。

Figure 3 A working model of HIPP proteins in biotic and abiotic stress tolerance in plants The expressions of some HIPPs could be affected by environmental stress stimuli (such as light, drought, cold, salt and pathogen attack). Under abiotic stresses, HIPPs interact with target proteins to activate downstream signaling, such as drought/cold responses and salicylic acid synthesis pathway thereby to enhance plant resistance or tolerance. By contrast, in some biotic stresses, a couple of HIPPs with target proteins have been shown to play negative roles in plant immunity via protein-protein interactions.

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植物HIPP家族蛋白结构和功能研究进展

Research Advances of Structure and Function of HIPP Family in Plants

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