Chinese Scientists Reveal Genome-wide Off-targeted Editing of Cytosine Base Editor
Received date: 2019-01-21
Accepted date: 2019-01-22
Online published: 2019-02-22
Targeted base editing with CRISPR-Cas systems is a breakthrough in genome editing technologies and is widely used in studies of humans, animals and plants. Recently, Chinese scientists discovered that the cytosine base editor (CBE) including BE3 and HF1-BE3 but not the adenine base editor (ABE) has substantial promise for genome-wide off-targeted editing in rice. This discovery is of great significance to the application and further optimization of targeted base editing.
Key words： base editing; CRISPR; off-targeting
Kabin Xie . Chinese Scientists Reveal Genome-wide Off-targeted Editing of Cytosine Base Editor[J]. Chinese Bulletin of Botany, 2019 , 54(3) : 296 -299 . DOI: 10.11983/CBB19033
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