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植物学报 >

2024 , Vol. 59 >Issue 6: 0 - 0

DOI: https://doi.org/10.11983/CBB24085

特邀综述

PPR蛋白参与细胞器RNA C→U的编辑机制的研究进展

  • 于晓琳 ,
  • 李西雅 ,
  • 夏冰玉洁 ,
  • 李昊 ,
  • 谭保才 ,
  • 王勇
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  • 山东大学生命科学学院, 植物发育与环境适应生物学教育部重点实验室, 青岛266237

收稿日期: 2024-06-01

  修回日期: 2024-08-02

  网络出版日期: 2024-08-28

基金资助

国家自然科学基金(No.32101640)

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Research advance of PPR proteins involved in the mechanism of organelle RNA C→U editing

  • YU Xiao-Lin ,
  • LI Xi-Ya ,
  • YAN Bing-YuJi ,
  • LI Hao ,
  • TAN Bao-Cai ,
  • YU Yong
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  • Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China

Received date: 2024-06-01

  Revised date: 2024-08-02

  Online published: 2024-08-28

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摘要

植物线粒体和叶绿体是半自主细胞器, 具有自己的基因组。转录后加工是细胞器基因正确表达必需的, 其中RNA C→U的编辑是非常关键的一种转录后加工过程。RNA编辑需要多种编辑因子的参与, 其中PPR蛋白编辑因子负责编辑位点的识别和PPR-DYW蛋白的DYW结构域催化胞嘧啶到尿嘧啶的脱氨过程。该文旨在综述PPR蛋白参与RNA C→U编辑机制的最新研究进展和人工合成PPR编辑因子潜在的应用价值。

关键词： PPR蛋白;  RNA C→U编辑;  线粒体;  叶绿体

本文引用格式

于晓琳 , 李西雅 , 夏冰玉洁 , 李昊 , 谭保才 , 王勇 . PPR蛋白参与细胞器RNA C→U的编辑机制的研究进展[J]. 植物学报, 2024 , 59(6) : 0 -0 . DOI: 10.11983/CBB24085

Abstract

Mitochondria and chloroplasts harboring themselves genomes are semi-autonomous organelles. Post-transcriptional processing is essential for the expression of organelle genes, one of which is RNA C→U editing. Multiple editing factors were reported to involve in RNA C→U editing. The PPR-motifs array in PPR proteins specifically target editing sites, and the DYW domains in PPR-DYW proteins catalyze the deaminase in the cytidine (C)-to-uridine (U) editing. This paper aims to review the recent advance which PPR proteins involve in RNA C→U editing, and the potential application value of synthetic PPR editing factors.

Key words： PPR proteins;  RNA C→U editing;   mitochondria;   chloroplasts

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