收稿日期: 2019-02-23
录用日期: 2019-04-03
网络出版日期: 2019-04-03
Open a Door of Defenses: Plant Resistosome
Received date: 2019-02-23
Accepted date: 2019-04-03
Online published: 2019-04-03
夏石头, 李昕 . 开启防御之门: 植物抗病小体[J]. 植物学报, 2019 , 54(3) : 288 -292 . DOI: 10.11983/CBB19035
Nucleotide binding, leucine-rich repeat (NLR) immune receptors are a major family of plant resistance (R) proteins, which are also found in animals. NLRs turn on immune signaling by recognizing pathogen-specific effectors in plants. Although the first few plant NLR R genes were cloned more than 25 years ago, the activation mechanism remained elusive. No structure is available for the full-length plant NLRs despite attempts over the last 2 decades. Recently, studies from the Chai, Zhou and Wang labs, published in Science, solved the structure of zygote arrest 1 (ZAR1) before and after effector recognition, which fills a huge gap in NLR biology. This mini review briefly summarized these findings and related progresses, and highlighted further challenges in NLR-mediated immune signaling field.
Key words： plant immunity; NLR; ZAR1; allosteric activation; resistosome
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