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植物环核苷酸门控离子通道及其功能研究进展
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- 1中国科学院植物研究所, 北京 100093
2杭州师范大学生命与环境科学学院, 杭州 310036
3北京林业大学生物科学与技术学院, 北京 100083
? 共同第一作者
收稿日期: 2014-08-07
录用日期: 2014-10-25
网络出版日期: 2015-09-06
基金资助
国家重点基础研究发展规划(No.2011CB809103)、国家自然科学基金创新研究群体科学基金(No.31121065)、国家自然科学基金(No.31270224, No.31401149)、高等学校学科创新引智计划(No.111 project, B13007)、长江学者和创新团队发展计划(No;IRT13047)及中央高校基本科研业务费专项资金(No;BLX2014-19)
Recent Advances in Cyclic Nucleotide-gated Ion Channels with their Functions in Plants
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- 1Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
2College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China
3College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China
? These authors contributed equally to this paper
Received date: 2014-08-07
Accepted date: 2014-10-25
Online published: 2015-09-06
摘要
环核苷酸门控离子通道(CNGC)是非选择性的阳离子通道, 可以直接被细胞内信使小分子——环核苷酸(cAMP和cGMP)活化。该通道蛋白包含6个跨膜α-螺旋, C端各具一个交叠的环核苷酸与钙调蛋白结合区。CNGC广泛存在于各种植物细胞中。研究表明, 模式植物拟南芥(Arabidopsis thaliana)的CNGC家族有20个成员, 分为4个亚群, 它们在抗病、花粉管生长、对Ca2+响应、抵抗重金属离子毒害和抗盐等多种信号途径中发挥重要作用, 协助植物细胞应对各种生物与非生物胁迫。该文简要介绍了CNGC的结构、表达谱及其调控因子, 并着重总结了近年来CNGC生物学功能的研究进展, 以期为今后系统开展其功能研究提供理论依据。
本文引用格式
刘海娇, 杜立群, 林金星, 李瑞丽 . 植物环核苷酸门控离子通道及其功能研究进展[J]. 植物学报, 2015 , 50(6) : 779 -789 . DOI: 10.11983/CBB14146
Abstract
Cyclic nucleotide-gated channels (CNGCs) are non-selective cation channels that can be activated directly by cytosolic second messengers, such as the CNs cGMP and cAMP. CNGCs have six predicted transmembrane α-helices, followed by a cyclic nucleotide-binding domain (CNBD) and a highly conserved calmodulin-binding domain (CaMBD); the latter two domains partially overlap at the C-terminal cytosolic region. CNGCs exist widely in different kinds of plant cells. In the model plant Arabidopsis, CNGCs represent 20 members divided into four groups. A large body of evidence showed that the CNGCs play essential roles in various signaling pathways, including pathogen responses, pollen tube growth, Ca2+ signaling, tolerance to heavy metal poisoning and resistance to salinity and thus assist the plant cell response to various biological and abiotic stresses. This review focuses on the structure, expression profile and regulatory factors of CNGCs, with special emphasis on recent progress in biological functions, which will provide valuable information for further study on CNGCs in plants.
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