The GRAS family is a class of plant specific transcription factors, playing essential roles in plant development and light signal transduction pathways. 33 GRAS family genes were identified in Arabidopsis genome. In this study, we found a group of GRAS family genes in response to osmotic and/or drought stresses through Arabidopsis GeneChip data mining. Meanwhile, we conducted co-expression analysis and gene ontology (GO) analysis and predicted that SCL13 was possibly involved in the response to osmotic stress. Our study will be helpful to elucidate some GRAS family genes related in signal transduction pathways during water stress, and be beneficial to crop molecular breeding in the future.