Plant growth regulators are natural or artificially synthesized chemical substances that play an important regulatory role in the growth and development of crops, as well as enhance the resistance of plants to stress. To study the effects of different plant growth regulators on the growth and development of wheat under salt-alkali stress, and to explore methods to increase crop yield in saline-alkaline land, we conducted spraying experiments on wheat in saline-alkaline soil in the Yellow River Delta Agricultural High-tech Industry Demonstration Zone from 2023 to 2024. The experiment was divided into four groups: a distilled water control group, a 0.5% Alginate oligosaccharide group, a Plant Gold group, and a mixed group of 0.5% Alginate oligosaccharide and Plant Gold. The wheat was sprayed on March 28, April 12, April 28, and May 12, 2024. The results showed that after spraying Alginate oligosaccharide and its mixture with Plant Gold, the number of grains per ear and the weight of 100 grains of wheat significantly increased. In particular, the group that received the mixture of Alginate oligosaccharide and Plant Gold achieved a theoretical yield of 234.9 kg per mu for wheat in saline-alkaline soil, which was an increase of 14.4% and 46.9% compared to the groups that received only Alginate oligosaccharide and Plant Gold, respectively. Therefore, the combined application of Alginate oligosaccharide and Plant Gold can significantly enhance the adaptability of wheat in saline-alkaline land, demonstrating its important application potential in wheat production in such environments.