Cryptochromes (CRYs) are blue light receptors that regulate various plant responses. CRYs exist in the dark as an inactive monomer, which absorbs photons and undergo conformational changes and oligomerization. Light alters the affinity between CRYs and interacting proteins, thereby regulating the transcription or stability of photoresponsive proteins to modulate plant growth and development. A recent study has discovered a sophisticated mechanism of CRY2 function, which is not only ‘activated’ by blue light but also by dark signals, thus constructing a more energy-efficient mode of light and dark signal dependent photoreceptor signaling. The authors found that CRY2 can inhibit cell division in root meristematic tissue even in the dark, regulate root elongation and growth, and control the expression of a large number of genes. FL1 and FL3 bind to the chromatin of cell division genes to promote their transcription. It is interesting that only the CRY2 monomer in the dark interacts with FL1/FL3, thereby inhibiting FL1/FL3 to promote root elongation, while blue light releases this inhibitory effect. This discovery reshapes people’s understanding of light receptors, and provides a new perspective for understanding plant perception and response to different signals to regulate growth and adaptability. Moreover, it is highly enlightening for a deeper understanding of sophisticated gene regulation.