Research Advances in Oxysterol-binding Protein-related Proteins

doi:10.11983/CBB21045

Abstract

Abstract: Membrane lipids not only are important components of cell membranes, but also participate in signal transduction as signal molecules. The uneven distribution of lipid molecules in membranes requires specific types of transport channels and transporters for each lipid type. Oxysterol-binding protein (OSBP)-related proteins (ORPs) are a highly conserved family of lipid transport proteins that recognize and transport phosphoinositides and sterols, which are involved in many physiological processes including signal transduction, vesicle transport, lipid metabolism and non-vesicle transport, and hence play a very important role in the growth and development of individual organism. In recent years, a series of important findings have been made on the structure and function of ORPs in mammals and yeasts, but the advances in plants are relatively slow. In this paper, we review the progress of ORPs research in mammals, yeasts and plants, analyze the structural domains of ORPs in plants and the phylogenetical relationship to their homologs in mammals and yeasts, and also provide perspectives on the directions of plant ORPs research in the future.

Key words: oxysterol-binding protein-related proteins, lipid transport, membrane contact site

Wenjiao Zou, Lei Ge, Qian Yu. Research Advances in Oxysterol-binding Protein-related Proteins[J]. Chinese Bulletin of Botany, 2021, 56(5): 627-640.

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URL: https://www.chinbullbotany.com/EN/10.11983/CBB21045

https://www.chinbullbotany.com/EN/Y2021/V56/I5/627

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References 129

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蛋白	膜结合位点	运输脂类	参考文献
OSBP	ER (endoplasmic reticulum)- trans-Golgi	Cholesterol, PI4P	Mesmin et al., 2013
ORP1	ER-late endosome/lysomes	Cholesterol	Rocha et al., 2009; Kobuna et al., 2010; Vihervaara et al., 2011
ORP2	ER-lipid droplet, ER-PM (plasma membrane)	Cholesterol, PI(4,5)P2	Hynynen et al., 2009; Jansen et al., 2011; Weber-Boyvat et al., 2015b; Wang et al., 2019
ORP3	ER-PM	PI4P	Weber-Boyvat et al., 2015a; Gulyás et al., 2020
ORP4	Unknown	Cholesterol	Wyles et al., 2007
ORP5	ER-PM, ER-late endosome?	PS, PI4P, cholesterol, PI(4,5)P₂	Du et al., 2011; Chung et al., 2015; Ghai et al., 2017
ORP6	ER-PM	PI4P	Mochizuki et al., 2018
ORP7	Unknown	Unknown	None
ORP8	ER-PM, ER-mitochondrion	PS, PI4P	Chung et al., 2015; Ghai et al., 2017
ORP9	ER-trans-Golgi	Cholesterol, PI4P	Ngo and Ridgway, 2009; Liu and Ridgway, 2014
ORP10	Unknown	PS	Maeda et al., 2013
ORP11	trans-Golgi-late endosome	Unknown	Zhou et al., 2010
Osh1p	Nucleus-vacuole junction	Cholesterol, ergosterol, PI4P	Levine and Munro, 2001; Schulz et al., 2009
Osh2p	ER-PM	Cholesterol	Schulz et al., 2009
Osh3p	ER-PM	PI4P, Cholesterol	Schulz et al., 2009; Tong et al., 2013
Osh4p	ER-PM, ER-mitochondrion	Sterol, PI4P, PI(4,5) P₂	Raychaudhuri et al., 2006; Schulz et al., 2009; de Saint-Jean et al., 2011; von Filseck et al., 2015b
Osh5p	Unknown	Cholesterol	Schulz et al., 2009
Osh6p	ER-PM	PS, PI4P	Wang et al., 2005a; Maeda et al., 2013
Osh7p	ER-PM	PS, PI4P	Maeda et al., 2013

蛋白	膜结合位点	运输脂类	参考文献
OSBP	ER (endoplasmic reticulum)- trans-Golgi	Cholesterol, PI4P	Mesmin et al., 2013
ORP1	ER-late endosome/lysomes	Cholesterol	Rocha et al., 2009; Kobuna et al., 2010; Vihervaara et al., 2011
ORP2	ER-lipid droplet, ER-PM (plasma membrane)	Cholesterol, PI(4,5)P2	Hynynen et al., 2009; Jansen et al., 2011; Weber-Boyvat et al., 2015b; Wang et al., 2019
ORP3	ER-PM	PI4P	Weber-Boyvat et al., 2015a; Gulyás et al., 2020
ORP4	Unknown	Cholesterol	Wyles et al., 2007
ORP5	ER-PM, ER-late endosome?	PS, PI4P, cholesterol, PI(4,5)P₂	Du et al., 2011; Chung et al., 2015; Ghai et al., 2017
ORP6	ER-PM	PI4P	Mochizuki et al., 2018
ORP7	Unknown	Unknown	None
ORP8	ER-PM, ER-mitochondrion	PS, PI4P	Chung et al., 2015; Ghai et al., 2017
ORP9	ER-trans-Golgi	Cholesterol, PI4P	Ngo and Ridgway, 2009; Liu and Ridgway, 2014
ORP10	Unknown	PS	Maeda et al., 2013
ORP11	trans-Golgi-late endosome	Unknown	Zhou et al., 2010
Osh1p	Nucleus-vacuole junction	Cholesterol, ergosterol, PI4P	Levine and Munro, 2001; Schulz et al., 2009
Osh2p	ER-PM	Cholesterol	Schulz et al., 2009
Osh3p	ER-PM	PI4P, Cholesterol	Schulz et al., 2009; Tong et al., 2013
Osh4p	ER-PM, ER-mitochondrion	Sterol, PI4P, PI(4,5) P₂	Raychaudhuri et al., 2006; Schulz et al., 2009; de Saint-Jean et al., 2011; von Filseck et al., 2015b
Osh5p	Unknown	Cholesterol	Schulz et al., 2009
Osh6p	ER-PM	PS, PI4P	Wang et al., 2005a; Maeda et al., 2013
Osh7p	ER-PM	PS, PI4P	Maeda et al., 2013