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植物学报 >

2024 , Vol. 59 >Issue 4: 529 - 532

DOI: https://doi.org/10.11983/CBB24090

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水稻“混血杂交”群体揭示遗传互作奥秘

  • 王淏 ,
  • 钦鹏 ,
  • 李仕贵
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  • 1四川农业大学水稻研究所, 成都 611130
    2西南作物基因资源发掘与利用国家重点实验室, 成都 611130
*李仕贵, 四川农业大学水稻研究所教授、博士生导师。荣获国家杰出青年科学基金、四川省科技杰出贡献奖和何梁何利基金奖, 被遴选为国家“百千万”人才工程国家级人选, 全国先进工作者, 全国农业科研杰出人才, 四川省天府万人计划杰出人才和农业大师。主要从事水稻遗传与育种研究。针对西南稻区生态环境, 开展了重穗型杂交稻核心种质及基因组序列研究, 定位克隆了系列控制穗粒结构和灌浆充实等有重要育种价值的新基因, 研究完善了水稻轮回群体改良方法, 形成了提高重穗型杂交稻亲本选育效率的技术体系, 育成了川农1A、蜀恢527和498等重穗型杂交稻骨干亲本, 组配出系列重穗型杂交稻新品种, 其中农业部认定为超级稻6个, 推广种植约6.7×106 hm2, 产生了巨大的社会经济价值。先后荣获国家和省部级奖励10余项, 其中国家科技进步二等奖3项, 四川科技进步一等奖4项; 在Cell、Science Advance、Nature Communications和Molecular Plant等期刊发表论文200余篇。E-mail: lishigui_sc@263.net

收稿日期: 2024-06-07

  录用日期: 2024-06-21

  网络出版日期: 2024-07-05

基金资助

国家自然科学基金委区域联合基金(U22A20465)

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The Rice "hybrid" Population Reveals the Mysteries of Genetic Interaction

  • Hao Wang ,
  • Peng Qin ,
  • Shigui Li
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  • 1Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China
    2State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Chengdu 611130, China

Received date: 2024-06-07

  Accepted date: 2024-06-21

  Online published: 2024-07-05

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摘要

基因互作与表型的内在关系是生命科学研究的关键问题, 大部分表型受多基因协同控制, 除加性效应外还存在显性和上位性等复杂遗传效应。最近一项研究构建了包含18 421个永久株系的水稻“混血杂交”群体, 成功鉴定到控制16个农艺性状的96个高置信候选基因, 通过分析基因间上位性效应, 构建了包含19个枢纽基因的遗传互作网络, 揭示出基因间潜在的互作效应, 发现170个“掩蔽”型上位互作对。该工作建立了作物遗传学研究的新范式, 且为水稻(Oryza sativa)遗传研究提供了重要数据和材料资源, 极大地加速了重要性状相关基因的挖掘, 推动了数量性状基因遗传互作的功能解析, 为分子设计育种奠定了理论基础。

关键词： “混血杂交”群体; 数量性状; 遗传多效性; 上位性

本文引用格式

王淏 , 钦鹏 , 李仕贵 . 水稻“混血杂交”群体揭示遗传互作奥秘[J]. 植物学报, 2024 , 59(4) : 529 -532 . DOI: 10.11983/CBB24090

Abstract

Revealing the intrinsic relationship between gene interactions and phenotypes is a key issue in life science research. Most phenotypes are controlled by multiple genes in a coordinated manner, exhibiting complex genetic effects such as dominance and epistasis in addition to additive effects. In a recent study, a “hybrid” population of rice containing 18 421 recombinant inbred lines was constructed, successfully identifying 96 high-confidence candidate genes controlling 16 agronomic traits. The study analyzed the epistatic effects among genes, constructed a genetic interaction network consisting of 19 hub genes, revealed potential interactions among genes, and discovered 170 “masking” epistatic interac-tions. This research provides important data and material resources for genetic studies in rice, establishes a new paradigm for crop genetics research, greatly accelerates the discovery of genes related to important traits, advances the functional analysis of quantitative trait gene interactions, and provides genetic resources and theoretical support for mole-cular breeding.

Key words： “hybrid” population; quantitative traits; genetic pleiotropy; epistasis

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