淫羊藿类黄酮生物合成相关基因研究进展

范雪兰; 落艳娇; 徐超群; 郭宝林

doi:10.11983/CBB23133

植物学报 >

2024 , Vol. 59 >Issue 5: 834 - 846

DOI: https://doi.org/10.11983/CBB23133

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淫羊藿类黄酮生物合成相关基因研究进展

范雪兰 ,
落艳娇 ,
徐超群 ,
郭宝林

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¹中国医学科学院北京协和医学院药用植物研究所, 中草药物质基础与资源利用教育部重点实验室, 北京 100193
²江西中医药大学, 南昌 330000
³中国中医科学院中医药健康产业研究所, 南昌 330000

第一联系人：† 共同第一作者

*徐超群, 中国医学科学院药用植物研究所助理研究员。主要研究方向为淫羊藿苷类成分的合成调控和高含量品种定向培育。参与国家自然科学基金等多个项目。主持重庆中药研究院开放课题及企业合作横向课题3项, 参与中国医学科学院创新工程以及四川省区域创新合作等项目。以第一作者在Frontiers in Plant Science和Giga Science等杂志发表论文10篇。E-mail: cqunxu@implad.ac.cn;
郭宝林, 研究员, 博士生导师, 中国医学科学院药用植物研究所药用植物鉴定中心副主任; 国家新药评审中心中药资源咨询专家, 中国植物学会药用植物和植物药专业委员会委员。承担国内外科研项目30余项; 发表论文290余篇, 主持编撰《中华医学百科全书·药用植物学》等著作11部; 培育药用植物新品种5个。目前其研究团队结合生产需求, 在药用植物分类鉴定、生理生态、遗传育种等基础上, 进行资源评估、新品种培育、大田栽培等技术研发、服务、评估和咨询; 并基于前沿多组学技术解析植物次生代谢途径, 揭示植物次生代谢的空间分布规律, 发掘和优化次生代谢相关元件, 通过代谢工程或合成生物学技术实现天然药物的绿色高效合成。E-mail: blguo@implad.ac.cn

收稿日期: 2023-09-22

录用日期: 2024-03-18

网络出版日期: 2024-04-02

基金资助

中国医学科学院医学与健康科技创新工程(2021-I2M-1-031)

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Research Progress on Genes Related to Flavonoids Biosynthesis in Herba Epimedii

Fan Xuelan ,
Luo Yanjiao ,
Xu Chaoqun ,
Guo Baolin

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¹Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicines, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China
²Jiangxi University of Chinese Medicine, Nanchang 330000, China
³Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang 330000, China

First author contact:† These authors contributed equally to this paper

Received date: 2023-09-22

Accepted date: 2024-03-18

Online published: 2024-04-02

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摘要

淫羊藿(Herba Epimedii)是一种历史悠久的中草药(TCM), 药用价值高, 国内淫羊藿相关研究备受关注。黄酮醇苷类(PFGs)成分是淫羊藿的主要活性物质, 其含量决定了药用品质。了解淫羊藿类黄酮生物合成途径, 挖掘与淫羊藿黄酮醇苷类含量相关的基因, 阐明其生物合成途径的调控机制对于提高淫羊藿品质至关重要。该文系统综述了淫羊藿类黄酮生物合成相关结构基因和转录因子基因研究进展, 为揭示黄酮含量的分子调控机制, 进而为淫羊藿分子育种和黄酮醇苷的合成生物学研究奠定理论基础。

关键词： 淫羊藿; 黄酮醇苷; 生物合成; 结构基因; 调控基因

本文引用格式

范雪兰 , 落艳娇 , 徐超群 , 郭宝林 . 淫羊藿类黄酮生物合成相关基因研究进展[J]. 植物学报, 2024 , 59(5) : 834 -846 . DOI: 10.11983/CBB23133

Abstract

Herba Epimedii is a traditional Chinese herb medicine (TCM) with a long history. Research on Herba Epimedii has attracted much attention in China due to its high medicinal value. C8-prenylated flavonol glycosides (PFGs) have been demonstrated to be the main bioactive components in Epimedium brevicornu, and their content determines the medicinal quality. Understanding the biosynthesis pathway of PFGs, exploring genes related to PFGs content, and elucidating the regulatory mechanisms of PFGs biosynthesis pathway is fundamental and essential for improving the quality of E. brevicornu. Here, we provide a comprehensive review of the research on structural and transcriptional factor genes related to the biosynthesis of PFGs, which not only contributes to unravel the regulatory mechanisms related to PFGs content, but also lay a foundation for research on molecular breeding and the synthetic biology in Epimedium plants.

Key words： Herba Epimedii; flavonol glycosides; biosynthesis; structural genes; regulatory genes

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