植物学报 ›› 2022, Vol. 57 ›› Issue (4): 412-421.DOI: 10.11983/CBB22016
吴楠1,2, 覃磊1,2, 彭志红1, 夏石头1,2,*()
收稿日期:
2022-01-16
接受日期:
2022-04-24
出版日期:
2022-07-01
发布日期:
2022-07-14
通讯作者:
夏石头
作者简介:
* E-mail: xstone0505@hunau.edu.cn基金资助:
Wu Nan1,2, Qin Lei1,2, Peng Zhihong1, Xia Shitou1,2,*()
Received:
2022-01-16
Accepted:
2022-04-24
Online:
2022-07-01
Published:
2022-07-14
Contact:
Xia Shitou
摘要: 系统获得性抗性(SAR)是一种因病原微生物初次侵染植物局部叶片而被激活的整株水平上的持久广谱抗性。在初次侵染部位快速产生的抗性信号, 可通过韧皮部传输到植物其它部位, 从而激活SAR。哌啶酸/N-羟基哌啶酸(Pip/NHP)作为新发现的移动信号分子, 在SAR信号通路中具有重要作用。该文综述了Pip/NHP的合成、转运以及对SAR调控作用的最新研究进展。
吴楠, 覃磊, 彭志红, 夏石头. 系统获得性抗性移动信号Pip/NHP研究进展. 植物学报, 2022, 57(4): 412-421.
Wu Nan, Qin Lei, Peng Zhihong, Xia Shitou. Research Progress of Mobile Signal Pip/NHP in Systemic Acquired Resistance. Chinese Bulletin of Botany, 2022, 57(4): 412-421.
图1 哌啶酸(Pip)/N-羟基哌啶酸(NHP)的生物合成途径及其对系统获得性抗性(SAR)的调控作用 图示病原体诱导的SAR建立过程中的调控网络。NHP与水杨酸(SA)共同驱动主要的SAR诱导途径。SA由ICS1、EDS5和PBS3从分支酸(CA)开始合成, Pip由ALD1和SARD4从赖氨酸(Lys)开始合成, 再通过FMO1进一步合成NHP。Pip/NHP可通过韧皮部转运到远端叶片, 而SA通过SA甲基转移酶(MeSA)的形式转移到远端叶片。因此, 系统叶组织中的NHP水平开始升高, 从而启动NPR1依赖的转录SAR反应, 且NHP水平升高优先于SA, 因此NHP还能通过间接上调SA的方式激活SAR反应。此外, NHP/SA诱导的转录反应通过增加UGT76B1和其它分解代谢酶的活性, 将SA和NHP转化成葡糖基水杨酸(SAG)和NHP-N-O-葡萄糖苷(NHPG), 从而降低SAR活性代谢物NHP和SA的水平, 在系统水平上降低或终止SAR反应。棕色路线代表SA途径; 蓝色路线代表Pip/NHP途径; T型箭头表示抑制作用; 棕色和蓝色虚线表示长距离运输; 红色虚线表示病原菌的诱导。
Figure 1 Biosynthetic pathway of pipecolic acid (Pip)/N-hydroxy-pipecolic acid (NHP) and its regulation in systemic acquired resistance (SAR) Figure shows a schematic diagram of regulatory network in the process of pathogen induced SAR establishment. NHP and SA jointly drives the main SAR induction pathway. While SA is synthesized from chorismic acid (CA) by ICS1, EDS5 and PBS3, Pip is synthesized from Lys by ALD1 and SARD4, and then NHP is further synthesized by FMO1. Pip/NHP can be transported to distal leaves through phloem, while SA can be transferred to distal leaves in the form of MeSA. Therefore, the level of NHP in leaf tissue of the system begins to rise, which starts the NPR1 dependent transcriptional SAR response, and the increase of NHP level takes priority with SA, which means, NHP can also activate the SAR response by indirectly upregulating SA. In addition, NHP/SA induced transcriptional response converts SA and NHP into SA-O-b-glucoside (SAG) and NHP-N-O-glucoside (NHPG) by increasing the activities of UGT76B1 and other catabolic enzymes, thereby reducing the levels of SAR active metabolites NHP and SA and reducing or terminating SAR response at the system level. Brown route represents SA pathway; Blue route represents Pip/NHP pathway; T-shaped arrow indicates inhibition; Brown and blue dotted lines indicate long-distance transportation; Red dotted line indicates the induction of pathogen.
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