Structure and Function of Copper Transporters in Plants

doi:10.11983/CBB15149

Abstract

Abstract: Copper (Cu) is an essential micronutrient involved in many physiological and biochemical reactions in growth and development in plants. Cu deficiency or excess can affect plant metabolism. Therefore, a series of Cu transporters are needed to act synergistically to sustain Cu homeostasis in plants. Plant Cu transporters can be classified into 2 general classes — Cu-uptake transporters (e.g., COPT, ZIP and YSL protein families) and Cu-efflux transporters (e.g., HMA protein family) — responsible for membrane transport of Cu and mediating Cu uptake and efflux. Recent studies have shown that some Cu chaperone protein families may be evolved from Cu transporter protein families, and Cu chaperones play an important role in maintaining Cu homeostasis. Here, we review developments in the expression, structure, location and function of Cu transporters as well as Cu chaperones.

Jinhong Yuan, Jingrui Li, Haiyan Zhang. Structure and Function of Copper Transporters in Plants[J]. Chinese Bulletin of Botany, 2016, 51(6): 849-858.

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URL: https://www.chinbullbotany.com/EN/10.11983/CBB15149

https://www.chinbullbotany.com/EN/Y2016/V51/I6/849

Figures/Tables 2

Figure 1 The COPT family of Cu transport proteins (modified from Peñarrubia et al., 2010)(A) Alignment of the putative Arabidopsis thaliana COPT Cu transporters; (B) The proposed topological structure of the COPT proteins; (C) The spatial disposition of TM2 in the human Ctr1 homotrimer complex. M: Met; G: Gly; C: Cys

Figure 2 Schematic illustration of the topology and main domains present in P1B-type ATPases (Arguello et al., 2007)H1-H8: Transmembrane segments; TM-MBS: Transmembrane metal binding sites; N-MBD: N-terminal metal binding domain; C-MBD: C-terminal metal binding domain. A, P and N: The maindo-mains present in P1B-type ATPases

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