Chin Bull Bot ›› 2011, Vol. 46 ›› Issue (5): 575-585.doi: 10.3724/SP.J.1259.2011.00575

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Systematic Metabolic Engineering of ω-7 Fatty Acids in Plants

Yongmei Wu, Xue Mao, Shujian Wang, Jinai Xue, Xiaoyun Jia, Jiping Wang, Zhirong Yang, Runzhi Li*   

  1. Center for Agricultural Biotechnology, Shanxi Agricultural University, Taigu 030801, China
  • Received:2011-04-06 Revised:2011-07-07 Online:2011-09-01 Published:2011-09-01
  • Contact: Runzhi Li E-mail:rli2001@hotmail.com
  • Supported by:

    ;Key Project of Chinese Ministry of Education;Natural Science Foundation of Shanxi; Program for the Top Young Academic Leaders of Higher Institutions of Shanxi;Breeding Fund of Shanxi Agricultural University;Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China

Abstract: Omega-7(ω-7) fatty acids (FAs) such as C16:1Δ9, C18:1Δ11 and C20:1Δ13, particularly palmitoleate (C16:1Δ9), are an important contributor to human health and are highly valued in pharmaceutical and industrial applications. A number of natural wild plants can synthesize high levels of these unusual FAs in seeds, but low yields and poor agronomic properties of those plants preclude their commercial use for ω-7 FA production. The lipid metabolic pathway has been genetically modified to develop engineered common oil crops that can highly produce and accumulate ω-7 FAs in seeds and represents a key hot-spot in biotechnology and renewable bio-based resources. The major targets for modification in the oil biosynthesis pathway include expression of various Δ9 desaturases, increasing substrate (C16:0) levels, co-expression of plastidial and endoplasmic reticulum Δ9 desaturases and optimizing the metabolic flux into triacylglycerols (TAGs). Here, we summarize our current understanding of ω-7 FA biosynthesis and its regulation and describe the advances in ω-7 FA metabolic engineering. We also discuss the current “bottleneck” in this field and potential breakthroughs by combining lipidomics, transgenics and other “-omics”. These new tools will provide a valued platform for mining genes involved in ω-7 FA biosynthesis and regulation. With this knowledge, we will develop more rational designs for metabolically engineering the commercial production of ω-7 FA in established oilseeds for human health and sustainable development of the related industry.

CLC Number: 

  • 中图分类号Q81

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