植物NLR免疫受体的识别、免疫激活与信号调控

覃磊¹^,², 彭志红², 夏石头¹^,²^,^*(

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Recognition, Immune Activation and Signal Regulation of Plant NLR Immune Receptor

Lei Qin¹^,², Zhihong Peng², Shitou Xia¹^,²^,^*(

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图1. NLRs的结构组成及与效应蛋白的识别模式(改自Duxbury et al., 2021)
(A) 植物NLRs的结构域分为3类, 包括中间部位的核苷酸结合域(NBD)和C端的富含亮氨酸重复序列(LRR)结构域以及N端的TIR、CC或类RPW8的CC结构域; (B) 植物NLRs识别效应蛋白的不同模式: 一些植物NLR直接与相应的效应蛋白结合, 或通过保卫蛋白或诱饵蛋白间接检测病原体效应蛋白; 此外, 一些植物NLRs具有特异的整合结构域(ID), 介导效应蛋白的识别。

Figure 1. Structural composition of NLRs and its recognition pattern to effector proteins (modified from Duxbury et al., 2021)
(A) The domains of plant NLRs are divided into three categories, including a central nucleotide-binding (NB) domain, a C-terminal leucine-rich repeats (LRR) region and N-terminal TIR, CC, or RPW8-like CC domain; (B) Different patterns of effector recognition by plant NLRs: Some plant NLRs directly bind to the corresponding effector proteins or indirectly detect the pathogen effector through the guardee or decoy proteins; Some plant NLRs have special integrated domains (ID) to mediate effector recognition.