植物TOR激酶响应上游信号的研究进展

孟彦彦¹^,^2†, 张楠¹^,^2†, 熊延¹^,²^,^*(

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Novel Links in the Plant Target of Rapamycin Signaling Networks

Yanyan Meng¹^,^2†, Nan Zhang¹^,^2†, Yan Xiong¹^,²^,^*(

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图2. 植物TOR复合体1的上游调控因子
植物TOR复合体1感知多重上游信号, 并可能以二聚体的形式发挥作用。其中糖-能量信号、氮/磷/硫营养信号、生长素-ROP2信号以及赤霉素信号是TOR上游的激活信号; 脱落酸-SnRK2信号和冷胁迫信号是TOR上游的抑制信号; 不同病毒对TOR的作用不同, 既有促进也有抑制。FKBP12-雷帕霉素和ATP竞争性抑制剂Torin1/2、AZD8055、WYE132/354以及KU-63794均可特异且高效地抑制TOR激酶活性。红色箭头代表激活作用, 绿色T形线条代表抑制作用, 黑色线条代表兼具激活和抑制作用。

Figure 2. The upstream regulators of TOR complex 1 (TORC1) in plants
TORC1 in plants senses multiple upstream signals, and probably functions as a dimerization form. Glucose-energy, nitrogen/phosphate/sulfur, auxin-ROP2, and GA signals are positive upstream regulators of TOR; ABA-SnRK2 and cold stress are negative upstream regulators of TOR; viruses play both positive and negative roles on TOR activity. FKBP12- rapamycin and ATP competitive inhibitors Torin1/2, AZD8055, WYE132/354 and KU-63794 inhibit plant TOR kinase activity specifically and efficiently. The red arrows represent activation, the green T shape lines mean repression, and the black line represents both activation and repression exist.