植物TOR激酶响应上游信号的研究进展

孟彦彦¹^,^2†, 张楠¹^,^2†, 熊延¹^,²^,^*(

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Novel Links in the Plant Target of Rapamycin Signaling Networks

Yanyan Meng¹^,^2†, Nan Zhang¹^,^2†, Yan Xiong¹^,²^,^*(

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图1. 动、植物中TOR蛋白的结构域和复合体组分
(A) 动、植物中TOR复合体1 (TORC1)。TORC1主要包含TOR、RAPTOR及LST8三个组分。动、植物中的TOR蛋白高度保守, 均由HEAT重复域、FAT、FRB、激酶域及FATC五个结构域组成。其中, HEAT重复域与RAPTOR结合; 激酶域与LST8结合; FRB结构域可被FKBP12介导与雷帕霉素结合。(B) 动物中TOR复合体2 (TORC2)。动物TORC2主要包含TOR、RICTOR、SIN1及LST8四个组分。其中RICTOR与SIN1互作并与HEAT重复域结合, LST8同样与激酶域结合。而尚未在植物中鉴定到RICTOR和SIN1的同源基因, 暗示TORC2在植物中可能不保守。

Figure 1. The domain structures and components of TOR complexes in plants and animals
(A) TOR complex 1 (TORC1) in plants and animals. TORC1 mainly contains TOR, RAPTOR and LST8. TOR protein is highly conserved among plants and animals, composed of HEAT repeats, FAT, FRB, kinase and FATC domains. RAPTOR binds to the HEAT repeats, LST8 binds to the kinase domain, and FKBP12 mediates interact between the FRB domain and rapamycin. (B) TOR complex 2 (TORC2) in animals. TORC2 mainly contains TOR, RICTOR, SIN1 and LST8 in animal. RICTOR interacts with SIN1 and binds to HEAT repeats, and LST8 binds to the kinase domain. Either RICTOR or SIN1 has no homologous genes in plants, which indicates that TORC2 is not conserved.