氧化甾醇结合蛋白相关蛋白家族的研究进展
邹文娇1,3, 葛磊2, 予茜2,*()
Research Advances in Oxysterol-binding Protein-related Proteins
Wenjiao Zou1,3, Lei Ge2, Qian Yu2,*()

图1. 氧化固醇结合蛋白(OSBP)在内质网和高尔基体之间膜结合位点转运胆固醇的功能模式图(改自Mesmin et al., 2013; Pietrangelo and Ridgway, 2018)
OSBP通过FFAT基序与VAP27-A互作, 定位于内质网, 通过PH蛋白结构域定位在高尔基体。OSBP一般通过Coiled-coil结构域形成二聚体行使功能。ORD蛋白结构域在磷脂酰肌醇-4-磷酸(PI4P)逆行转运的驱动下, 将胆固醇从内质网转移到高尔基体。

Figure 1. Working model of oxysterol-binding protein (OSBP) function in cholesterol transportation at membrane contact site (MCS) between endoplasmic reticulum (ER) and trans-Golgi (modified from Mesmin et al., 2013; Pietrangelo and Ridgway, 2018)
OSBP is located in ER by FFAT motif interacting with VAP27-A and in trans-Golgi by the PH domain. OSBP usually forms dimers through the Coiled-coil domain to play its role. The ORD domain could move cholesterol from the ER to trans-Golgi, driven by the retrograde transport of phosphatidylinositol-4-phosphate (PI4P).