氧化甾醇结合蛋白相关蛋白家族的研究进展

邹文娇, 葛磊, 予茜

Research Advances in Oxysterol-binding Protein-related Proteins

Wenjiao Zou, Lei Ge, Qian Yu

表1 动物及酵母中ORPs的亚细胞定位及功能

Table 1 Subcellular localization and function of ORPs in animal and yeast

蛋白 膜结合位点 运输脂类 参考文献 OSBP ER (endoplasmic reticulum)- trans-Golgi Cholesterol, PI4P Mesmin et al., 2013 ORP1 ER-late endosome/lysomes Cholesterol Rocha et al., 2009; Kobuna et al., 2010; Vihervaara et al., 2011 ORP2 ER-lipid droplet, ER-PM (plasma membrane) Cholesterol, PI(4,5)P2 Hynynen et al., 2009; Jansen et al., 2011; Weber-Boyvat et al., 2015b; Wang et al., 2019 ORP3 ER-PM PI4P Weber-Boyvat et al., 2015a; Gulyás et al., 2020 ORP4 Unknown Cholesterol Wyles et al., 2007 ORP5 ER-PM, ER-late endosome? PS, PI4P, cholesterol, PI(4,5)P2 Du et al., 2011; Chung et al., 2015; Ghai et al., 2017 ORP6 ER-PM PI4P Mochizuki et al., 2018 ORP7 Unknown Unknown None ORP8 ER-PM, ER-mitochondrion PS, PI4P Chung et al., 2015; Ghai et al., 2017 ORP9 ER-trans-Golgi Cholesterol, PI4P Ngo and Ridgway, 2009; Liu and Ridgway, 2014 ORP10 Unknown PS Maeda et al., 2013 ORP11 trans-Golgi-late endosome Unknown Zhou et al., 2010 Osh1p Nucleus-vacuole junction Cholesterol, ergosterol, PI4P Levine and Munro, 2001; Schulz et al., 2009 Osh2p ER-PM Cholesterol Schulz et al., 2009 Osh3p ER-PM PI4P, Cholesterol Schulz et al., 2009; Tong et al., 2013 Osh4p ER-PM, ER-mitochondrion Sterol, PI4P, PI(4,5) P2 Raychaudhuri et al., 2006; Schulz et al., 2009; de Saint-Jean et al., 2011; von Filseck et al., 2015b Osh5p Unknown Cholesterol Schulz et al., 2009 Osh6p ER-PM PS, PI4P Wang et al., 2005a; Maeda et al., 2013 Osh7p ER-PM PS, PI4P Maeda et al., 2013