图2. 细胞分裂素信号转导途径中的分子间相互作用(改自Lomin et al. 2018; Arkhipov et al. 2019)
细胞分裂素信号被膜定位的组氨酸(His)激酶受体感受, 通过His磷酸转移蛋白被传递到细胞核, 从而激活细胞核中的转录因子家族。CK: 细胞分裂素; ATP: 腺苷三磷酸; ADP: 腺苷二磷酸; P: 磷酸; D: 保守的天冬氨酸; H: 保守的His; DI: 感受器模块的二聚体界面结构域; PAS和PAS-like: 感受器模块的CHASE结构域的子结构域; TM1和TM2: 跨膜结构域1和2; HisKA (DHpD): His激酶A结构域(二聚合作用和His磷酸转移结构域); H-ATPase (CAD): 腺苷三磷酸酶结构域(催化与ATP结合结构域); REC-like: 类接收器结构域; REC: 接收器结构域; HPt: 含有His的磷酸转移蛋白(磷酸传递蛋白); RR-B: B型反应调控因子(转录因子)。蛋白-蛋白相互作用(PPI)用红色虚线表示。

Figure 2. Intermolecular interactions in the cytokinin signaling pathway (modified from Lomin et al. 2018; Arkhipov et al. 2019)
Cytokinin signaling is perceived by membrane-localized Histidine (His) kinase receptors and is transduced to nucleus through a His phosphotransfer protein to activate a family of transcription factors in the nucleus. CK: Cytokinin; ATP: Adenosine triphosphate; ADP: Adenosine diphosphate; P: Phosphate; D: Conserved Aspartate; H: Conserved His; DI: Dimerization interface domain of the sensor module; PAS and PAS-like: Subdomains of the CHASE domain of the sensor module; TM1 and TM2: Transmembrane domain 1 and 2; HisKA (DHpD): His kinase A domain (dimerization and His phosphotransfer domain); H-ATPase (CAD): Adenosine triphosphatase domain (catalytic and ATP-binding domain); REC-like: Receiver-like domain; REC: Receiver domain; HPt: His-containing phosphotransfer protein (phosphotransmitter); RR-B: Type B response regulator (transcription factor). Protein-protein interactions (PPI) are indicated by a red dotted line.