中国科学家发现胞嘧啶单碱基编辑工具存在 基因组范围的脱靶
谢卡斌(
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Chinese Scientists Reveal Genome-wide Off-targeted Editing of Cytosine Base Editor
Kabin Xie()
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图1. 基于CRISPR-Cas9的单碱基编辑
(A) 利用脱氨酶进行DNA碱基转换的原理; (B) 胞嘧啶编辑器(CBE, 以BE3为例)和腺嘌呤编辑器(ABE)的结构示意图。L: 连接肽
Figure 1. CRISRP-Cas9 base editing
(A) Deaminase-mediated base editing reactions; (B) The schematic structure of cytosine (CBE, take BE3 as an example) and adenine (ABE) base editors. L: Peptide linker
