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我国科学家在程序性细胞死亡机制研究领域取得重大突破

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  • 作物生物学国家重点实验室, 山东农业大学生命科学学院, 泰安 271018
† 共同第一作者。

收稿日期: 2018-04-10

  录用日期: 2018-05-01

  网络出版日期: 2018-09-11

Chinese Scientists Have Made a Great Breakthrough in the Mechanism of Programmed Cell Death

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  • State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Taian 271018, China
† These authors contributed equally to this paper

Received date: 2018-04-10

  Accepted date: 2018-05-01

  Online published: 2018-09-11

摘要

程序性细胞死亡在调控植物发育和胁迫响应中具有重要作用, 而活性氧是导致程序性细胞死亡的关键因子。日前, 中科院遗传与发育所李家洋研究组对活性氧调控程序性细胞死亡的分子机制进行了深度解析, 首次阐明了苹果酸作为信号分子, 经由叶绿体-线粒体穿梭途径而引发活性氧产生, 继而导致细胞死亡。该研究成果是程序性细胞死亡调控机制领域的重大突破。

本文引用格式

张宪省 . 我国科学家在程序性细胞死亡机制研究领域取得重大突破[J]. 植物学报, 2018 , 53(4) : 445 -446 . DOI: 10.11983/CBB18094

Abstract

Programmed cell death (PCD) plays important roles in regulating plant development and stress responses, and the reactive oxygen species (ROS) acts as the key regulator in PCD process. However, the underlying mechanism remains to be addressed. Recently, the Jiayang Li’s group from Institute of Genetics & Developmental Biology, Chinese Academy of Sciences has made great breakthroughs in the mechanism of PCD regulated by ROS. The group demonstrated that malate shuttling from the chloroplast to mitochondrion triggers ROS production and subsequent PCD in Arabidopsis. The study provides novel results for understanding the mechanism of PCD regulation.

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参考文献

1 Mou ZL, He YK, Dai Y, Liu XF, Li JY (2000). Deficiency in fatty acid synthase leads to premature cell death and dra- matic alterations in plant morphology.Plant Cell 12, 405-418.
2 Wu J, Sun YF, Zhao YN, Zhang J, Luo LL, Li M, Wang JL, Yu H, Liu GF, Yang LS, Xiong GS, Zhou JM, Zuo JR, Wang YH, Li JY (2015). Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species.Cell Res 25, 621-633.
3 Zhao YN, Luo LL, Xu JS, Xin PY, Guo HY, Wu J, Bai L, Wang GD, Chu JF, Zuo JR, Yu H, Huang X, Li JY (2018). Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana. Cell Res 28, 448-461.
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