Chin Bull Bot ›› 2011, Vol. 46 ›› Issue (5): 575-585.doi: 10.3724/SP.J.1259.2011.00575

Previous Articles     Next Articles

Systematic Metabolic Engineering of ω-7 Fatty Acids in Plants

Yongmei Wu, Xue Mao, Shujian Wang, Jinai Xue, Xiaoyun Jia, Jiping Wang, Zhirong Yang, Runzhi Li*   

  1. Center for Agricultural Biotechnology, Shanxi Agricultural University, Taigu 030801, China
  • Received:2011-04-06 Revised:2011-07-07 Online:2011-09-01 Published:2011-09-01
  • Contact: Runzhi Li E-mail:rli2001@hotmail.com
  • Supported by:

    ;Key Project of Chinese Ministry of Education;Natural Science Foundation of Shanxi; Program for the Top Young Academic Leaders of Higher Institutions of Shanxi;Breeding Fund of Shanxi Agricultural University;Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China

Abstract: Omega-7(ω-7) fatty acids (FAs) such as C16:1Δ9, C18:1Δ11 and C20:1Δ13, particularly palmitoleate (C16:1Δ9), are an important contributor to human health and are highly valued in pharmaceutical and industrial applications. A number of natural wild plants can synthesize high levels of these unusual FAs in seeds, but low yields and poor agronomic properties of those plants preclude their commercial use for ω-7 FA production. The lipid metabolic pathway has been genetically modified to develop engineered common oil crops that can highly produce and accumulate ω-7 FAs in seeds and represents a key hot-spot in biotechnology and renewable bio-based resources. The major targets for modification in the oil biosynthesis pathway include expression of various Δ9 desaturases, increasing substrate (C16:0) levels, co-expression of plastidial and endoplasmic reticulum Δ9 desaturases and optimizing the metabolic flux into triacylglycerols (TAGs). Here, we summarize our current understanding of ω-7 FA biosynthesis and its regulation and describe the advances in ω-7 FA metabolic engineering. We also discuss the current “bottleneck” in this field and potential breakthroughs by combining lipidomics, transgenics and other “-omics”. These new tools will provide a valued platform for mining genes involved in ω-7 FA biosynthesis and regulation. With this knowledge, we will develop more rational designs for metabolically engineering the commercial production of ω-7 FA in established oilseeds for human health and sustainable development of the related industry.

CLC Number: 

  • 中图分类号Q81

No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Kang Le. The Chemical Defenses of plants to phytophagous Insects[J]. Chin Bull Bot, 1995, 12(04): 22 -27 .
[2] HUANG Kai-Yao;GUO Hou-Liang and YI Ping. Effects of Salt Stress on Cell Structure and N2 Fixation in Blue-Green Alga Anabaena cylindrica[J]. Chin Bull Bot, 1998, 15(03): 54 -56 .
[3] Zhang Jing-tan. Abbreviations for Some Commonly Used Term[J]. Chin Bull Bot, 1985, 3(01): 57 -58 .
[4] DU Gui-Sen;ZANG Yu-Long and WANG Mei-Zhi. Study on Spore Morphology of 6 Species of The Family Pottiaceae in China[J]. Chin Bull Bot, 1998, 15(03): 57 -60 .
[5] TIAN Xin-Zhi. On Plant Illustration and Artistic Drawing and Painting[J]. Chin Bull Bot, 1999, 16(04): 470 -476 .
[6] LI Xiu-Lan WU Cheng DENG Xiao-Jian YANG Zhi-Rong. Plant Height Genes and Their Progress of Molecular Biology Research in Rice[J]. Chin Bull Bot, 2003, 20(03): 264 -269 .
[7] LIU Hong-Tao LI Bing ZHOU Ren-Gang. Calcium_calmodulin Signal Transduction Pathway and Environment Stimulation[J]. Chin Bull Bot, 2001, 18(05): 554 -559 .
[8] Renyi Gui;Yadi Liu;Xiaoqin Guo;Haibao Ji;Yue Jia;Mingzeng Yu;Wei Fang*. Effects of Dose of 137Cs-γ Irradiation on Chlorophyll Fluorescence Parameters for Leaves of Seedlings of Phyllostachys heterocycla ‘Pubescens’[J]. Chin Bull Bot, 2010, 45(01): 66 -72 .
[9] Sanxiong Fu;Cunkou Qi*. Identification of Genes Differentially Expressed in Seeds of Brassica napus Planted in Nanjing and Lhasa by Arabidopsis Microarray[J]. Chin Bull Bot, 2009, 44(02): 178 -184 .
[10] Xiaofen Sun;Yu Chen;Junsong Pan;Yuliang Wang;Kexing Sun;Kexuan Tang*;Run Cai*. Correlation and Path Analyses of Vindoline with Major Agronomic Traits in Catharanthus roseus[J]. Chin Bull Bot, 2009, 44(01): 96 -102 .