Chin Bull Bot ›› 2011, Vol. 46 ›› Issue (2): 129-137.doi: 10.3724/SP.J.1259.2011.00129

    Next Articles

Recent Advances in Metabolic Products of Flavonoids in Punica granatum

Ancheng Liu1, Hui Li2,3, Liangsheng Wang2*, Changmin Pang1, Weiguang Wei1   

  1. 1Xi’an Botanical Garden of Shannxi Province, Xi'an 710061, China

    2Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China

    3Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2010-08-31 Revised:2010-12-16 Online:2011-05-09 Published:2011-03-01
  • Contact: Liangsheng Wang E-mail:wanglsh@ibcas.ac.cn

Abstract: Pomegranate (Punica granatum) is a cultivated fruit with a long history and great nutritional value. China has 8 major pomegranate-producing areas, including Xingyang and Kaifeng cities, Henan province; Lintong county, Shaanxi province; Zaozhuang county, Shandong province; Huaiyuan county, Anhui province; Huili county, Sichuan province; Mengzi county, Yunnan province; and Kargilik county, Xinjiang Uyghur autonomous region. In total, 33 flavonoids have been detected from pomegranate fruit juice, pericarp and foliage; these include 6 flavanols, 1 flavanone glycoside, 2 flavonols, 3 flavonol glycosides, 3 flavones, 5 flavone glycosides, 1 flavanonol glycoside, 3 anthocyanidins and 9 anthocyanins. These flavonoid compounds are widely used in the health food and medicinal industries. This paper summarizes the recent progress in the constitution, content, detection methods and pharmacological studies of flavonoids in the fruit, leaf and petal of P. granatum. To promote deeper research and use of the active components and for functional characterization for cancer prevention, future study should focus on the rapid analysis, semi-preparation and/or preparation separation, and quantitative analysis of flavonoids in fruits; germplasm resource evaluation; and identification of active components in leaves and flowers of pomegranate.

CLC Number: 

  • S6

迪莉拜尔?苏里坦,马木提?库尔班(2000).新疆石榴花中红色素理化性质的研究.食品科技(2), 40–41.
冯玉增,陈德均(2000).石榴优良品种与高效栽培技术.开封.河南科学技术出版社.
关海宁,刁小琴(2007).石榴汁花青素的制备与稳定性研究.饮料工业10(11),25–28.
郭长江,徐静,韦京豫,杨继军,吴健全(2008).我国常见水果类黄酮物质的含量. 营养学报30(2),130–135.
郭俊明,张德刚,张虹(2006).云南石榴花红色素的鉴定及其稳定性研究.江苏农业科学(1), 117–120.
郭玲(2006).新疆石榴生理活性物质的提取及其特性的研究. 硕士论文.合肥.安徽农业大学.pp.12–14,27.
郭松年,董周永,孙海燕,刘兴华(2008).石榴汁花色苷热稳定性及其降解动力学研究.农业工程学报24(3), 256–259.
何瑛,张有林,张国仁(2008).石榴果皮褐变产物的提取、分离与结构鉴定.食品工业科技29(4), 133–136.
萨提瓦尔地,艾克白尔,艾来提,热依木,阿不都拉?阿巴斯(2007).新疆石榴花中总黄酮提取工艺研究.食品科学28(3), 110–12.
沈皖梅,靳学远(2008a).石榴叶总黄酮抗氧化性质的研究.安徽农学通报14(21), 63–64.
沈皖梅,靳学远(2008b).超声辅助提取石榴叶中总黄酮工艺的研究.广西轻工业120(11),7–8.
孙云蔚,杜澍,姚昆德(1983).中国果树史与果树资源. 上海: 上海科学技术出版社.pp . 13.
索金玲,彭秧,张纵圆,王明力(2009).石榴叶总黄酮提取工艺及体外抗氧化性研究.生物技术19(1), 63–65.
田树革,魏玉龙,刘宏炳(2009). Folin-Ciocalteu 比色法测定石榴不同部位总多酚的含量. 光谱实验室26(2),341–344.
汪小飞,赵昌恒(2009).安徽观赏石榴品种资源及在园林中的应用研究.中国农学通报25(4),171–174.
文泽富,张迎君,谢永红(1995).石榴汁花色素昔稳定性预测.四川果树(1), 1–2.
吴静,支金虎(2006).石榴叶中总黄酮含量的测定.河西学院学报 22(2),49–50.
许宗运,蒋慧, 吴静, 应璐, 许飞利(2003).石榴皮和石榴渣总黄酮含量的测定. Chinese Agricultural Science Bulletin 19(13),72–74.
张来新,李宁(2007).石榴花色素的提取及稳定性研究.化工时刊 21(10), 16–20.
张立华,孙晓飞,张艳侠,张元湖(2009).石榴花化学成分及生物活性研究进展. 山东农业科学3,33–35, 50.
张四普,汪良驹(2008). 23个石榴基因型遗传多样性的SRAP 分析.果树学报25( 5) , 655–660.
赵迎丽,李建华,王春生(2008).石榴果实采后生理变化与贮藏保鲜研究进展.保鲜与加工48 ,11–14.
郑艺梅,刘长华,陈树坤,华平(2008).石榴皮和石榴籽组分的差异性分析. 农产品加工?学刊(12),36–37,49.
李云峰,郭长江,杨继军(2004).石榴皮抗氧化物质提取及其体外抗氧化作用研究.营养学报26(2),144–47.
阿布都热西提?阿布力克木,李茵萍,买里克扎提?买合木提(2006).超声波法提取石榴籽中黄酮及其含量的测定.化学与生物工程23(12),34–35.
杨建宇, 陈韵, 郑春兰, 舒晔(2008).石榴的生物活性及其抗炎和抗肿瘤作用.云南大学学报(自然科学版)30(S1),430–438.
Artik N, Murakami H, Mori T (1998). Determination of phenolic compounds in pomegranate juice by using HPLC. Fruit Process 12, 492–499.
Cárdenas M, Marder M, Blank VC, Roguin LP (2006). Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines. Bioorg Med Chem 14, 2966–2971.
Celik I, Temur A, Isik I (2009). Hepatoprotective role and antioxidant capacity of pomegranate (Punica granatum) flowers infusion against trichloroacetic acid-exposed in rats. Food Chemi Toxicol 47, 145–149.
Cook NC, Samman S (1996). Flavonoids - Chemistry, metabolism, cardioprotective effects, and dietary sources. J Nutr Biochem 7, 66–76.
de Pascual-Teresa S, Santos-Buelga C, Rivas-Gonzalo JC (2000). Quantitative analysis of flavan-3-ols in Spanish foodstuffs and beverages. J Agric Food Chem 48, 5331–5337.
Dufour C, Loonis M (2007). Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. Biochimi Biophys Acta 1770, 958–965.
Fadavi A, Barzegar M, Azizi M, Bayat M (2005). Physicochemical composition of ten pomegranate cultivars (Punica granatum L.) grown in Iran. Food Sci Tech Int 11(2), 113–119.
Fuentes Fiallo VR, Exposito Montoya A (1995). Las encuestas etnobotanicas sobre plantas medicinales en Cuba. Rev Jardín Botán Nac 26, 77-145.
Gracious Ross R, Selvasubramanian S, Jayasundar S (2001). Immunomodulatory activity of Punica granatum in rabbits – a preliminary study. J Ethnopharmacol 78, 85–87.
Hernandez F, Melgarejo P, Tomas-Barberan FA, Artes F (1999). Evolution of juice anthocyanins during ripening of new selected pomegranate (Punica granatum) clones. Eur Food Res Technol 210, 39–42.
Jaiswal V, DerMarderosian A, Porter JR (2010). Anthocyanins and polyphenol oxidase from dried arils of pomegranate (Punica granatum L.). Food Chem 118,11–16.
Kim ND, Mehta R, Yu W, Neeman I, Livney T, Amichay A, Poirier D, Nicholls P, Kirby A, Jiang W, Mansel R, Ramachandran C, Rabi T, Kaplan B, Lansky E (2002). Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Tr 71, 203–217.
Kulkarni AP, Aradhya SM (2005). Chemical changes and antioxidant activity in pomegranate arils during fruit development. Food Chem 93, 319–324.
Lansky EP, Newmana RA (2007). Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol 109, 177–206.
Lommen A, Godejohann M, Venema DP, Hollman PCH, Sp raulM. (2000). Application of directly coupled HPLC-NMR-MS to the identification and confirmation of quercetin glycosides and phloretin glycosides in apple peel. Anal Chem 72(8),1793–1797.
Masa A, Vilanova M, Pomar F (2007). Varietal differences among the flavonoid profiles of white grape cultivars studied by high-performance liquid chromatography. J Chromatog A 1164,291–297.
Mousavinejad G, Emam-Djomeh Z, Rezaei K, Khodaparast MHH (2009). Identification and quantification of phenolic compounds and their effects on antioxidant activity in pomegranate juices of eight Iranian cultivars. Food Chem 115, 1274–1278
Nawwar MAM, Hussein SAM, Merfort L (1994). Leaf phenolics of Punica granatum L. Phytochemistry 37, 1175–1177.
Noda Y, Kaneyuka T, Mori A, Packer L (2002). Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin. J Agric Food Chem 50, 166–171.
Ozgen M, Durgac C, Serce S, Kaya C (2008). Chemical and antioxidant properties of pomegranate cultivars grown in the Mediterranean region of Turkey. Food Chem 111, 703–706.
Park HJ, Cha HC (2003). Flavonoids from leaves and exocarps of the grape Kyoho. Korean J Biol Sci 7, 327– 330.
Scalbert A, Williamson G (2000). Dietary intake and bioavailability of polyphenols. J Nutr 130, 2073S–2085S.
Shwartz E, Glazer I, Bar-Ya’akov I, Matityahu I, Bar-Ilan I, Hollandb D, Amir R (2009). Changes in chemical constituents during the maturation and ripening of two commercially important pomegranate accessions. Food Chem 115, 965–973.
Sudheesh S, Vijayalakshmi NR (2005). Flavonoids from Punica granatum - potential antiperoxidative agents. Fitoterapia 76 , 181–186.
Syed DN, Afaq F, Mukhtar H (2007). Pomegranate derived products for cancer chemoprevention. Semin Cancer Biol 17, 377–385.
Tsao R, Yang R, Young JC, Zhu HH (2003). Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). J Agric Food Chem 51, 6347–6353.
van Elswijk DA, Schobel UP, Lansky EP, Irth H, van der Greef J (2004). Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry 65, 233–241.
Yusuph M, Mann J (1997). A triglyceride from Punica granatum. Phytochemistry 44 (7), 1391–1392.
No related articles found!
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Hu Shi-yi. Fertilization in Plants IV. Fertilization Barriers Inoompalibilty[J]. Chin Bull Bot, 1984, 2(23): 93 -99 .
[2] JIANG Gao-Ming. On the Restoration and Management of Degraded Ecosystems: with Special Reference of Protected Areas in the Restoration of Degraded Lands[J]. Chin Bull Bot, 2003, 20(03): 373 -382 .
[3] . [J]. Chin Bull Bot, 1994, 11(专辑): 65 .
[4] . [J]. Chin Bull Bot, 1996, 13(专辑): 103 .
[5] ZHANG Xiao-Ying;YANG Shi-Jie. Plasmodesmata and Intercellular Trafficking of Macromolecules[J]. Chin Bull Bot, 1999, 16(02): 150 -156 .
[6] Chen Zheng. Arabidopsis thaliana as a Model Species for Plant Molecular Biology Studies[J]. Chin Bull Bot, 1994, 11(01): 6 -11 .
[7] . [J]. Chin Bull Bot, 1996, 13(专辑): 13 -16 .
[8] LEI Xiao-Yong HUANG LeiTIAN Mei-ShengHU Xiao-SongDAI Yao-Ren. Isolation and Identification of AOX (Alternative Oxidase) in ‘Royal Gala’ Apple Fruits[J]. Chin Bull Bot, 2002, 19(06): 739 -742 .
[9] Chunpeng Yao;Na Li. Research Advances on Abscisic Acid Receptor[J]. Chin Bull Bot, 2006, 23(6): 718 -724 .
[10] Li Wang, Qinqin Wang, Youqun Wang. Cytochemical Localization of ATPase and Acid Phosphatase in Minor Veins of the Leaf of Vicia faba During Different Developmental Stages[J]. Chin Bull Bot, 2014, 49(1): 78 -86 .