植物成熟microRNA转录后修饰与降解的研究进展

植物学报 ›› 2014, Vol. 49 ›› Issue (4): 483-489.DOI: 10.3724/SP.J.1259.2014.00483

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植物成熟microRNA转录后修饰与降解的研究进展

张俊红¹, 张守攻², 齐力旺^2*, 童再康^1*

¹浙江农林大学亚热带森林培育国家重点实验室培育基地, 临安 311300
²中国林业科学研究院林业研究所细胞生物学实验室, 北京 100091

收稿日期:2013-12-23 修回日期:2014-04-23 出版日期:2014-07-01 发布日期:2014-08-08
通讯作者: 童再康, 齐力旺
基金资助:
国家自然科学基金重点项目;国家自然科学基金

Research Advances in Post-transcriptional Modification and Degradation of Mature MicroRNAs in Plants

Junhong Zhang¹, Shougong Zhang², Liwang Qi^2*, Zaikang Tong^1*

¹Nurturing Station for the State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Lin’an 311300, China;

²Laboratory of Cell Biology, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China

Received:2013-12-23 Revised:2014-04-23 Online:2014-07-01 Published:2014-08-08
Contact: Zaikang Tong, Liwang Qi

摘要/Abstract

摘要： microRNA(miRNA)是一类长度为20–24 nt的内源小RNA, 广泛存在于各种植物体内, 参与调控植物器官的形态建成、激素应答、逆境胁迫和营养代谢等一系列过程。虽然miRNA生物合成和功能研究已取得了很大进展, 但关于植物成熟miRNA的转录后修饰和降解的研究却报道较少。一方面miRNA如同其它RNA存在半衰期, 其降解对于调控细胞内miRNA含量起重要作用, 从而调控植物的生长发育或胁迫响应等过程; 另一方面, 成熟miRNA存在转录后修饰, 可影响miRNA的稳定性, 最终影响其活性。该文着重从植物成熟miRNA的转录后修饰和降解等方面进行了综述。

Abstract: MicroRNAs (miRNAs) are a class of endogenous small RNA molecules, 20–24 nt, found in diverse plants. MiRNAs function as transcriptional and post-transcriptional regulators of gene expression. They play essential roles in developmental and physiological processes of plants, including organ morphogenesis, responses to hormones and environmental stresses, and nutrition metabolism. Although progresses have been made in the biosynthesis and functional identification of miRNAs in plants, post-transcriptional modification or degradation of miRNAs in plants remains elusive. On one hand, miRNAs will be degraded, which is crucial to control the miRNA content in cells, thus regulating the growth, development and stress response in plants. On the other hand, the post-transcriptional modification of mature miRNAs might be associated with miRNA stability. Several studies have demonstrated that adenylation increases miRNA stability, while uridylation boosts degradation. This review will focus on research progress in post-transcriptional modification and degradation of mature miRNAs in plants, hopefully to provide useful information for miRNA destiny in plants.

张俊红, 张守攻, 齐力旺, 童再康. 植物成熟microRNA转录后修饰与降解的研究进展. 植物学报, 2014, 49(4): 483-489.

Junhong Zhang, Shougong Zhang, Liwang Qi, Zaikang Tong. Research Advances in Post-transcriptional Modification and Degradation of Mature MicroRNAs in Plants. Chinese Bulletin of Botany, 2014, 49(4): 483-489.

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